OPTIMIZATION OF EXCIPIENT USED IN CELERY LEAF (Apium graveolens) EXTRACT CAPSULE FORMULATION

MICHELLE P SIDHARTA, Prof. Dr.rer.nat. Triana Hertiani, S.Si., M.Si., Apt.; apt. Daryanto, S.Si. (PT. Sido Muncul)

2022 | Skripsi | S1 FARMASI

Herbal medicine is one of the rising trends in modern times, used to not only provide supplements but in times also to provide prevention of deadly diseases. One of the uses of herbal medicine is celery to treat hypertension, the "silent killer" and the cause of the highest mortality rate in the world. However, there are few studies on using celery herb extract as an antihypertensive agent. Additionally, the difference in extraction method may cause a difference in the extract characteristics, resulting in formulation difference. Therefore, this research aims to find the most optimum excipient provided by the research area to use in the celery herb extract capsule. This study used a pure experimental method using celery herb extracts formulated in capsule dosage forms. The excipients used in this research are Silicon dioxide, Microcrystalline Cellulose 102, Starch, Talcum, and Magnesium Stearate. Eight formulas were constructed for this study, with each of them varying between the amount of each excipient and the type of filler being put into each Formula. Each Formula was assessed differently based on the step that the research was on. Generally, the formulas were assessed based on their organoleptic, moisture content, granule flowability, tapped density, disintegration testing, active ingredients testing, and microbial testing excluding aflatoxin and heavy metals testing. These tests were referred to Indonesia's National Agency for Food and Drugs Control law number 32 of the year 2019 about the Requirements for Safety and Quality of Traditional Medicine. The result of each test was then compared to the set requirement, and the Formula chosen for pilot testing was based on the requirement. The Formula chosen for pilot testing was composed of the following excipients: 10% Silicon Dioxide, 80% of Microcrystalline Cellulose 102, 7% Amylum, 2% talcum, and 1% Magnesium Stearate. The Formula was assessed using the previous requirements for every step and has been found to have passed every requirement by Indonesia's National Agency for Food and Drugs Control and Internal Company Regulations, which suggested the Formula is composed of the most optimum excipient.

Herbal medicine is one of the rising trends in modern times, used to not only provide supplements but in times also to provide prevention of deadly diseases. One of the uses of herbal medicine is celery to treat hypertension, the "silent killer" and the cause of the highest mortality rate in the world. However, there are few studies on using celery herb extract as an antihypertensive agent. Additionally, the difference in extraction method may cause a difference in the extract characteristics, resulting in formulation difference. Therefore, this research aims to find the most optimum excipient provided by the research area to use in the celery herb extract capsule. This study used a pure experimental method using celery herb extracts formulated in capsule dosage forms. The excipients used in this research are Silicon dioxide, Microcrystalline Cellulose 102, Starch, Talcum, and Magnesium Stearate. Eight formulas were constructed for this study, with each of them varying between the amount of each excipient and the type of filler being put into each Formula. Each Formula was assessed differently based on the step that the research was on. Generally, the formulas were assessed based on their organoleptic, moisture content, granule flowability, tapped density, disintegration testing, active ingredients testing, and microbial testing excluding aflatoxin and heavy metals testing. These tests were referred to Indonesia's National Agency for Food and Drugs Control law number 32 of the year 2019 about the Requirements for Safety and Quality of Traditional Medicine. The result of each test was then compared to the set requirement, and the Formula chosen for pilot testing was based on the requirement. The Formula chosen for pilot testing was composed of the following excipients: 10% Silicon Dioxide, 80% of Microcrystalline Cellulose 102, 7% Amylum, 2% talcum, and 1% Magnesium Stearate. The Formula was assessed using the previous requirements for every step and has been found to have passed every requirement by Indonesia's National Agency for Food and Drugs Control and Internal Company Regulations, which suggested the Formula is composed of the most optimum excipient.

Kata Kunci : Herbal medicine, Celery Herb capsule, Anti-Hypertension