Ekspresi Signal Regulatory Protein Alpha pada Meningioma Orbitokranial
Sarah Rizqia Indrayanti, Prof. Dr. dr. Agus Supartoto Sp.M(K), Dr. dr. Retno Ekantini M.Kes Sp.M(K), dr. Ery Kus Dwianingsih, PhD. Sp.PA(K)
2023 | Tesis-Spesialis | S2 Ilmu Penyakit Mata
INTISARI
Ekspresi Signal Regulatory Alpha (SIRPa) pada Meningioma Orbitokranial
Sarah Rizqia Indrayanti1, Agus Supartoto1, Retno Ekantini1, Ery Kus Dwianingsih2
1Departemen Ilmu Kesehatan Mata, Fakultas Kedokteran, Kesehatan Masyarakat, dan Keperawatan, Universitas Gadjah Mada – RSUP Dr. Sardjito
2Departemen Patologi Anatomi, Fakultas Kedokteran, Kesehatan Masyarakat, dan Keperawatan, Universitas Gadjah Mada – RSUP Dr. Sardjito
Latar Belakang
Beberapa tumor padat dan tumor saraf memiliki sistem immune checkpoint untuk menghindar dari respon imun tubuh. Signal Regulatory Protein Alpha (SIRPa) merupakan protein transmembran yang merupakan salah satu sistem immune checkpoint dan diekspresikan oleh beberapa tumor padat dan tumor saraf. Meningioma, yang merupakan tumor padat yang berasal dari sel cap arachnoid, dapat memiliki sistem immune checkpoint termasuk SIRPa. Penelitian ini bertujuan untuk mengetahui ekspresi SIRPa pada meningioma orbitokranial.
Metode
Penelitian ini menggunakan metode potong lintang dengan sampel blok parafin jaringan meningioma dari RSUP Dr. Sardjito. Ekspresi SIRPa diperiksa dengan imunohistokimia. Hubungan ekspresi SIRPa dan derajat patologi meningioma dianalisis dengan SPSS chi-square.
Hasil
Seratus dua puluh sembilan (129) sampel diinklusi; sebanyak 121 (93.8%) merupakan perempuan dan 111 (86%) merupakan meningioma WHO grade 1. SIRPa terwarna pada 68 (52.2%) sampel. Hubungan antara ekspresi SIRPa dengan grading WHO dianalisa; SIRPa positif pada 59 (53.2%) WHO grade 1 dan 9 (50.0%) WHO grade 2-3 (p value = 0.804).
Kesimpulan
Penelitian ini merupakan penelitian pertama yang menemukan ekspresi SIRPa sebanyak 52.2% meningioma orbitokranial. Mengingat peran SIRPa pada sistem immune checkpoint, diperlukan studi lebih lanjut mengenai peran SIRPa pada meningioma untuk kemungkinan terapi di masa depan.
Expression of Signal Regulatory Alpha (SIRPa) on Orbitocranial Meningioma
Sarah Rizqia Indrayanti1, Agus Supartoto1, Retno Ekantini1, Ery Kus Dwianingsih2
1Department of Ophthalmology, Faculty of Medicine, Public Health, and Nursing, Gadjah Mada University – Dr Sardjito Hospital
2Department of Anatomical Pathology, Faculty of Medicine, Public Health, and Nursing, Gadjah Mada University – Dr Sardjito Hospital
Background
Several solid and neural tumors have immune checkpoint system to “escape” from body immune response. Signal Regulatory Protein Alpha (SIRPa) is a transmembrane protein that is one of immune checkpoint system and is expressed on several solid and neural tumors. Meningioma, a solid tumor that originated from arachnoid cap cells, may have immune checkpoint system including SIRPa. This study aimed to investigate the expression of SIRPa on orbitocranial meningioma.
Method
This was a cross-sectional study enrolling histopathological tissue from resected meningioma. Paraffin blocks of meningioma from Sardjito General Hospital were examined for SIRPa expression by immunohistochemistry. The relationship between SIRPa and meningioma grading were analyzed with SPSS chi square.
Results
One hundred twenty nine (129) samples were included; 121 (93.8%) were female and 111 (86%) were grade 1 WHO. SIRPa was positively stained on 68 (52.2%) samples with mean of staining percentage 32.64%. Relationship between SIRPa expression and WHO grading were analyzed, SIRPa was positive in 59 (53.2%) grade 1 WHO and 9 (50.0%) grade 2-3 WHO (p value = 0.804).
Conclusion
This was the first study that demonstrate SIRPa expression on orbitocranial meningioma (52.2%). Given the known role of SIRPa in immune checkpoint system, the role of SIRPa in meningioma should be further studied in importance to estimate the potential of future treatment.
Kata Kunci : Meningioma orbitokranial, SIRPa, immune checkpoint
