HUBUNGAN ANTARA RASIO APOLIPOPROTEIN B/APOLIPOPROTEIN A-I PLASMA DENGAN INDEKS MASSA TUBUH PASIEN INFARK MIOKARD AKUT

YENNI RADJALI, dr. Anggoro Budi Hartopo, M.Sc., Sp.PD., Ph.D ; dr.Royhan Rozqie, Ph.D

2015 | Skripsi | S1 PENDIDIKAN DOKTER

Latar Belakang :Infark miokard akut (IMA) merupakan salah satu penyebab kematian terbesar di dunia. Rasio apo B/apo A-I, indikator terbaik untuk menilai risiko infark miokard akut, meningkat pada pasien infark miokard akut. Selain itu, indeks massa tubuh yang tinggi merupakan faktor risiko untuk kejadian infark miokard akut. Apakah ada hubungan antara rasio apo B/apo A-I dengan indeks massa tubuh masih belum jelas. Tujuan : Tujuan penelitian ini adalah untuk menyelidiki korelasi antara indeks massa tubuh dan rasio apolipoprotein B/apolipoprotein A-I pasien infark miokardakut. Metode : Seratus dua puluh tiga sampel darah dari pasien IMA dipilih setelah dilakukan inklusi dan ekslusi. Kadar apolipoprotein B dan apolipoprotein A-I diukur secara imunoturbidimetri. Indeks massa tubuh dihitung berdasarkan rumus berat badan dalam kilogram dibagi dengan tinggi badan kuadrat dalam meter. Hasil pengukuran dianalisis dengan uji korelasi Pearson. Hasil : Uji korelasi Pearson menunjukkan adanya korelasi yang tidak bermakna antara rasio apolipoprotein B/apolipoprotein A-I dan indeks massa tubuh pada pasien infark miokard akut(r = -0,068, p = 0,452). Kesimpulan : Tidak terdapat korelasi yang bermakna antara rasio apolipoprotein B/apolipoprotein A-I dan indeks massa tubuh pada pasien infark miokard akut.

Background : Acute myocardial infarction (AMI) is one of the most common cause of mortality in the world. Apo B/apo A-I ratio which is a better indicator for diagnosing acute myocardial infarction, the concentration was higher in acute myocardial infarction patients. A high body mass index is one of the risk factors for acute myocardial infarction. Whether there is a correlation between apo B/apo A-I ratio and body mass index is still unclear. Objective : The aim of this study is to investigate the correlation between apolipoprotein B/apolipoprotein A-I ratio and body mass index in acute myocardial infarction Method : A hundred and twenty three blood samples were selected according to inclusion and exclusion criteria. Apolipoprotein B and apolipoprotein A-I were measured using imunoturbidimetric method. Body mass index was calculated based on formula weight in kilogram per height in meter squared. The results of these measurements were analysed using Pearson correlation test. Result : Pearson correlation test showed a non significant correlation between apolipoprotein B/apolipoprotein A-I and body mass index in acute myocardial infarction patients(r = -0,068, p = 0,452). Conclusion : There is no significant correlation between apolipoprotein B/apolipoprotein A-I ratio and body mass index in acute myocardial infarction patients.

Kata Kunci : Infark Miokard Akut, Rasio Apolipoprotein B/Apolipoprotein A-I, Indeks Massa Tubuh, Acute Myocardial Infarction, Apolipoprotein B/Apolipoprotein A-I Ratio, Body mass index