PENGARUH LATIHAN PASRAH DIRI (LPD) DITAMBAH FLUOXETIN DIBANDING FLUOXETIN TERHADAP PENURUNAN KADAR FRUKTOSAMIN PENDERITA PENGIDAP DIABETES MELITUS TIPE 2 DENGAN SIMTOM DEPRESI
NATSIR MUIN, dr. Agus Siswanto, SpPD-KPsi; Prof. dr.H.A.H. Asdie SpPD-KEMD
2015 | Tesis-Spesialis | SP Ilmu Penyakit DalamLatar Belakang. Depresi merupakan faktor risiko terjadinya diabetes dan diabetes meningkatkan risiko untuk terjadinya depresi. Depresi memberikan kontribusi terhadap perjalanan penyakit diabetes melitus. Pemeriksaan fruktosamin digunakan untuk memantau kontrol kadar gula darah selama 2-3 minggu (sesuai usia albumin). LPD menimbulkan respon relaksasi yang diharapkan mampu memperbaiki gejala stres atau gejala depresi. Tujuan penelitian. Untuk mengetahui penurunan kadar fruktosamin pada kelompok pasien diabetes melitus dengan gejala depresi setelah pemberian fluoxetin saja dibandingkan dengan kombinasi fluoxetin dan LPD. Metode. Penelitian ini dilakukan di RSUD Dr.Soeradji Tirtonegoro, Klaten pada bulan Mei-Agustus 2014. Distribusi atau sebaran data diuji menggunakan uji statistik Shapiro-Wilk. Perbedaan fruktosamin dan BDI (Beck Depression Inventory) sebelum dan sesudah perlakuan diuji dengan pair t-test jika terdistribusi normal atau Wilcoxon test jika tidak terdistribusi normal. Perbedaan penurunan fruktosamin dan BDI kedua kelompok dibandingkan dengan independent t-test jika terdistribusi normal atau Mann Whitney U test jika tidak terdistribusi normal. Perbedaan dianggap bermakna bila p < 0,05 dengan interval kepercayaan 95 %. Hasil Penelitian. Penurunan kadar fruktosamin secara bermakna pada kelompok perlakuan dari 293.90+-140.042 menjadi 259.02+-116.08 dengan p=0.017 juga dialami kelompok kontrol dengan penurunan fruktosamin dari 263.13+-163.65 menjadi 219.01+-149.33 dengan p=0.001. Penurunan kadar fruktosamin pada kelompok perlakuan 67.24+-102.71 tidak lebih baik daripada kelompok kontrol 71.14+-72.77dengan nilai p=0.902 (p>0.05). Kesimpulan. Penambahan LPD pada terapi fluoxetin tidak berpengaruh pada kadar fruktosamin penderita diabetes melitus tipe 2 dengan simtom depresi.
Background. Depression is a risk factor for diabetes and diabetes increase the risk for depression. Depression contributes to progression of diabetes mellitus. Examination of fructosamine is used to monitor blood sugar control for 2-3 weeks (according to age albumin). LPD evoke the relaxation response which is expected to improve symptoms of stress or depression. Objective. To determine the decrease in fructosamine levels in the group of patients with diabetes mellitus with depression symptoms after administration of fluoxetine alone compared with a combination of fluoxetine and LPD. Methods. This research was conducted in Dr.Soeradji Tirtonegoro Hospital, in May to August 2014. Distribution of data is tested using the Shapiro-Wilk test. The differences between fructosamine and BDI (Beck Depression Inventory) before and after treatment were tested with a pair t-test if normally distributed or Wilcoxon test if it is not normally distributed. The decrease in fructosamine and BDI both groups were compared by independent t-test if normally distributed or Mann Whitney U test if not normally distributed. Differences were considered significant if p <0.05 with a confidence interval of 95%. Result. There is a significant decrease in fructosamine levels in treatment group from 293.90+-140.042 to 239.01+-133.13 after treatment with p value 0.017 (p <0.05) and also in control group from 263.13+-163.65 to 219.01+-149.33 with p value 0.001 (p<0.05). But, the decrease of fructosamine levels not differ in the treatment group 67.24+-102.71 than the control group 71.14 +- 72.77 with p value = 0.902 (p> 0.05). Conclusion. LPD had no effect on fructosamine levels of type 2 diabetes mellitus patients with depression symptoms. Background. Depression is a risk factor for diabetes and diabetes increase the risk for depression. Depression contributes to progression of diabetes mellitus. Examination of fructosamine is used to monitor blood sugar control for 2-3 weeks (according to age albumin). LPD evoke the relaxation response which is expected to improve symptoms of stress or depression. Objective. To determine the decrease in fructosamine levels in the group of patients with diabetes mellitus with depression symptoms after administration of fluoxetine alone compared with a combination of fluoxetine and LPD. Methods. This research was conducted in Dr.Soeradji Tirtonegoro Hospital, in May to August 2014. Distribution of data is tested using the Shapiro-Wilk test. The differences between fructosamine and BDI (Beck Depression Inventory) before and after treatment were tested with a pair t-test if normally distributed or Wilcoxon test if it is not normally distributed. The decrease in fructosamine and BDI both groups were compared by independent t-test if normally distributed or Mann Whitney U test if not normally distributed. Differences were considered significant if p <0.05 with a confidence interval of 95%. Result. There is a significant decrease in fructosamine levels in treatment group from 293.90+-140.042 to 239.01+-133.13 after treatment with p value 0.017 (p <0.05) and also in control group from 263.13+-163.65 to 219.01+-149.33 with p value 0.001 (p<0.05). But, the decrease of fructosamine levels not differ in the treatment group 67.24+-102.71 than the control group 71.14 +- 72.77 with p value = 0.902 (p> 0.05). Conclusion. LPD had no effect on fructosamine levels of type 2 diabetes mellitus patients with depression symptoms.
Kata Kunci : LPD, simptom depresi, fruktosamin, BDI, beck depression index, symptom of depression, fructosamine
