EKSPRESI INTERLEUKIN-6 JARINGAN ADENOKARSINOMA KOLOREKTAL BERDASARKAN LOKASI TUMOR PRIMER

Novi Wijayanti S., dr. Neneng Ratnasari, Sp.PD, KGEH; Prof dr. Siti Nurdjanah, M.Kes, Sp.PD, KGEH

2015 | Tesis | SP Ilmu Penyakit Dalam

Latar belakang Interleukin-6 (IL-6) adalah pleiotropic cytokine yang diproduksi oleh sel tumor yang berfungsi sebagai faktor pertumbuhan. Kanker kolorektal memproduksi IL-6 sehingga peningkatan IL-6 di mukosa colon merupakan suatu tanda pertumbuhan sel yang berlebihan. Lokasi tumor menjadi salah satu faktor prognostik dalam kanker kolorektal tetapi belum jelas apakah ekspresi yang berlebihan dari IL-6 jaringan kanker kolorektal terkait erat dengan lokasi tumor primer. Tujuan Penelitian: Untuk mengetahui apakah terdapat perbedaan ekspresi IL-6 jaringan kanker antara kelompok yang berlokasi di kolon dan rektum pada pasien adenokarsinoma kolorektal di RSUP Dr. Sardjito Yogyakarta Metode: Penelitian dengan desain cross sectional dan subyek berupa preparat biopsi reseksi tumor adenokarsinoma kolorektal yang memenuhi kriteria inklusi dan esklusi. Analisis statistik menggunakan Statistical Product and Service Solutions (SPSS) 20.0 for Windows. Hasil Penelitian Dari 58 sampel penelitian, rerata usia pasien 56,70±12,55 tahun, subyek laki-laki 26 (44,8 %) orang dan nilai median ekspresi IL-6 sebesar 0,87. Lokasi tumor primer di rektum sebanyak 27 sampel (46,6%), kolon sisi kanan sebanyak 14 (24,1%) dan kolon sisi kiri sebanyak 17 (29,3%). Nilai ekspresi IL-6 jaringan kanker di kolon sedikit lebih tinggi dibandingkan di rektum meskipun secara statistik tidak bermakna (0,89(031- 0,99) vs 0,83(0,26-0,98); p = 0,458). Pada analisis subgrup juga tidak didapatkan perbedaan ekspresi IL-6 yang bermakna antara kolon kanan, kiri dan rektum (p= 0,338). Kesimpulan : Ekspresi IL-6 jaringan adenokarsinoma kolorektal di kolon lebih tinggi dibandingkan di rektum tetapi tidak berbeda signifikan secara statistik

Background Interleukin-6 (IL-6) is a pleiotropic cytokine produced by tumor cell that act as growth factor. Colorectal cancer can produce IL-6 as a consequence there is a raising of IL-6 level in colon mucosa that is showing excessive development of cell. Tumor location is one of prognostic factors in colorectal cancer but it is unclear that increase of IL-6 expression in colorectal cancer is related to primary tumor location. Objectives This reserach was held to find out the difference of tissue expression of IL-6 between which located in colon and rectum in colorectal adenocarcinoma in Sardjito Hospital Yogyakarta Methods : It was a cross sectional study. The subject of this study was the resection preparation of colorectal tissue biopsies from all patients with adenocarcinoma colorectal with tissue samples were sent to the department of Anatomical Pathology Dr. Sardjito Hospital that met the inclusion and exclusion criteria.Statistical analysis was done by Statistical Product and Service Solutions (SPSS) 20.0 for Windows. Results : 58 samples of this study had been analysed. They consisted of 26 male subjects (44.8%) with mean age of 56.70±12.55 years old and median value of interleukin 6 expression was 0.87 . In all 27 samples had rectum cancer (46.6%), 14 samples had right colon cancer (24.1%) and 17 samples had left colon cancer (29.3%). Level of IL-6 expression in colon cancer tissue was slightly higher than in the rectum although did not differ significant (0,89(0,31-0,99) vs 0,83(0,26-0,98) p = 0,458). In the subgroup analysis, the differences of IL-6 tissue expression was not significant between the right colon, left and rectum (p =0,338). Conclusion: Tissue expression of IL-6 in colon adenocarcinoma was higher than in rectum but this difference was not statistically significant

Kata Kunci : interleukin-6, tissue expression, colorectal adenocarcinoma, tumor location