0,05). Hasil pengukuran CCI menunjukkan berturut-turut median (IQR) sebesar 17.360 (12.350) dan 14.850 (13.250) pada TC manual dan semi-otomatis yang juga tidak berbeda bermakna secara statistik (p>0,05). Kesimpulan: Tidak ada perbedaan bermakna antara corrected count increment pasca transfusi TC yang dibuat secara manual dan semi-otomatis pada pasien hematologi-onkologi anak. Introduction: Thrombocytes concentrate (TC) transfusion is a primary supportive therapy for hematology-oncology pediatrics patients who suffer severe thrombocytopenia. The problem is approximately in 30-70% cases failed to show good response leading to the need for more transfusion. Transfusion response can be measured using corrected count increment (CCI) which is correlated with various clinical conditions. On the other hand, the number of platelet transfused from the TC will affect directly to CCI value. Different TC preparation technique can lead to different number of platelet yield in a TC. Considering the availability of two different preparation technique in Blood Service Unit (Unit Pelayanan Transfusi Darah/UPTD) RSUP Dr. Sardjito, it is important to compare corrected count increment between manually prepared and semi-automatically prepared thrombocytes concentrate. Method: This study is a cross-sectional observational study as a part of experimental study \\"Efficacy and Risk of Platelet Transfusion\\". Using consecutive sampling method, this study was carried out in UPTD RSUP Dr. Sardjito and Pediatric Hematology-Oncology Ward Estella in April-December 2014. The inclusion criteria was all Pediatric Hematology-Oncology Ward patients who requested platelet to UPTD RSUP Dr. Sardjito. The exclusion criteria was all patients who were diagnosed as suffering disseminated intravascular coagulation, on medication that affect CCI (Amfotericin B, Ciprofloxacin and Vancomycin) and scheduled for bone marrow transplantation or major surgery procedure. Results: There were 51 eligible subjects, 36 subjects were found to receive manually prepared thrombocyte concentrate and 15 subjects received semi-automatically prepared thrombocyte concentrate. All subjects were having similar characteristics between manual and semi-automatic groups. Thrombocyte concentrate had median (IQR) total platelet count of 1,3x1011 (IQR 1,1) and 1,6x1011 (IQR 1,2) in manual and semi-automatic group respectively, which showed no statistically significant difference (p>0,05). Calculation of CCI showed median (IQR) of 17.360 (12.350) and 14.850 (13.250) in manual and semiautomatic group respectively, which showed no statistically significant difference (p>0,05). Conclusion: There are no difference of corrected count increment in subjects receiving manually prepared thrombocyte concentrate compared to subjects receiving semi-automatically prepared thrombocyte concentrate."> 0,05). Hasil pengukuran CCI menunjukkan berturut-turut median (IQR) sebesar 17.360 (12.350) dan 14.850 (13.250) pada TC manual dan semi-otomatis yang juga tidak berbeda bermakna secara statistik (p>0,05). Kesimpulan: Tidak ada perbedaan bermakna antara corrected count increment pasca transfusi TC yang dibuat secara manual dan semi-otomatis pada pasien hematologi-onkologi anak. Introduction: Thrombocytes concentrate (TC) transfusion is a primary supportive therapy for hematology-oncology pediatrics patients who suffer severe thrombocytopenia. The problem is approximately in 30-70% cases failed to show good response leading to the need for more transfusion. Transfusion response can be measured using corrected count increment (CCI) which is correlated with various clinical conditions. On the other hand, the number of platelet transfused from the TC will affect directly to CCI value. Different TC preparation technique can lead to different number of platelet yield in a TC. Considering the availability of two different preparation technique in Blood Service Unit (Unit Pelayanan Transfusi Darah/UPTD) RSUP Dr. Sardjito, it is important to compare corrected count increment between manually prepared and semi-automatically prepared thrombocytes concentrate. Method: This study is a cross-sectional observational study as a part of experimental study \\"Efficacy and Risk of Platelet Transfusion\\". Using consecutive sampling method, this study was carried out in UPTD RSUP Dr. Sardjito and Pediatric Hematology-Oncology Ward Estella in April-December 2014. The inclusion criteria was all Pediatric Hematology-Oncology Ward patients who requested platelet to UPTD RSUP Dr. Sardjito. The exclusion criteria was all patients who were diagnosed as suffering disseminated intravascular coagulation, on medication that affect CCI (Amfotericin B, Ciprofloxacin and Vancomycin) and scheduled for bone marrow transplantation or major surgery procedure. Results: There were 51 eligible subjects, 36 subjects were found to receive manually prepared thrombocyte concentrate and 15 subjects received semi-automatically prepared thrombocyte concentrate. All subjects were having similar characteristics between manual and semi-automatic groups. Thrombocyte concentrate had median (IQR) total platelet count of 1,3x1011 (IQR 1,1) and 1,6x1011 (IQR 1,2) in manual and semi-automatic group respectively, which showed no statistically significant difference (p>0,05). Calculation of CCI showed median (IQR) of 17.360 (12.350) and 14.850 (13.250) in manual and semiautomatic group respectively, which showed no statistically significant difference (p>0,05). Conclusion: There are no difference of corrected count increment in subjects receiving manually prepared thrombocyte concentrate compared to subjects receiving semi-automatically prepared thrombocyte concentrate.">
Laporkan Masalah

PERBANDINGAN CORRECTED COUNT INCREMENT PASCA TRANSFUSI THROMBOCYTE CONCENTRATE YANG DIBUAT SECARA MANUAL DAN SEMI-OTOMATIS PADA PASIEN HEMATOLOGI-ONKOLOGI ANAK

MOHAMMAD RIZKI, dr. Teguh Triyono, M.Kes., Sp.PK-K

2015 | Tesis | SP ILMU PATOLOGI KLINIK

Latar Belakang: Pada 30-70% tindakan transfusi thrombocyte concentrate (TC) di pasien hematologi-onkologi anak terjadi kegagalan respon yang mengakibatkan pasien perlu ditransfusi lagi. Respon transfusi trombosit yang diukur dengan corrected count increment (CCI) dapat dipengaruhi oleh kondisi klinis pasien dan kondisi TC, terutama kandungan trombositnya. Teknik preparasi TC yang berbeda dapat memberikan jumlah trombosit dalam TC yang berbeda pula. Dengan adanya dua cara preparasi yang berbeda di Unit Pelayanan Transfusi Darah (UPTD) RSUP Dr. Sardjito, perlu dilakukan penelitian mengenai perbandingan CCI pasca transfusi TC yang dipersiapkan dengan dua cara yang berbeda, yaitu manual dan semi-otomatis. Metode: Penelitian ini merupakan penelitian belah lintang observasional yang merupakan bagian dari penelitian eksperimental \\"Risiko dan Efikasi Transfusi Trombosit\\". Sampling dilakukan dengan menggunakan metode consecutive sampling. Penelitian dilakukan di Unit Pelayanan Transfusi Darah Instalasi Laboratorium Klinik RSUP Dr. Sardjito dan Bangsal Hematologi-dan Onkologi Anak Estella Instalasi Kesehatan Anak pada bulan April-Desember 2014. Kriteria inklusi yang digunakan adalah pasien yang mengajukan permintaan komponen TC di UPTD RSUP Dr. Sardjito. Kriteria eksklusi yang digunakan adalah pasien yang mengalami disseminated intravascular coagulation, memperoleh obat yang mempengaruhi CCI dan pada masa penelitian harus menjalani transplantasi sumsum tulang atau operasi mayor. Hasil: Terdapat 51 subjek yang memenuhi kriteria inklusi dan eksklusi. Dari jumlah tersebut, 36 subjek memperoleh TC manual dan 15 memperoleh TC semi-otomatis. Analisis statistik menunjukkan tidak ada perbedaan bermakna pada karakteristik klinis subjek di kedua kelompok. Karakteristik TC menunjukkan median jumlah total trombosit berturut-turut 1,3x1011 (IQR 1,1) dan 1,6x1011 (IQR 1,2) pada TC manual dan semi-otomatis yang tidak berbeda bermakna secara statistik (p>0,05). Hasil pengukuran CCI menunjukkan berturut-turut median (IQR) sebesar 17.360 (12.350) dan 14.850 (13.250) pada TC manual dan semi-otomatis yang juga tidak berbeda bermakna secara statistik (p>0,05). Kesimpulan: Tidak ada perbedaan bermakna antara corrected count increment pasca transfusi TC yang dibuat secara manual dan semi-otomatis pada pasien hematologi-onkologi anak.

Introduction: Thrombocytes concentrate (TC) transfusion is a primary supportive therapy for hematology-oncology pediatrics patients who suffer severe thrombocytopenia. The problem is approximately in 30-70% cases failed to show good response leading to the need for more transfusion. Transfusion response can be measured using corrected count increment (CCI) which is correlated with various clinical conditions. On the other hand, the number of platelet transfused from the TC will affect directly to CCI value. Different TC preparation technique can lead to different number of platelet yield in a TC. Considering the availability of two different preparation technique in Blood Service Unit (Unit Pelayanan Transfusi Darah/UPTD) RSUP Dr. Sardjito, it is important to compare corrected count increment between manually prepared and semi-automatically prepared thrombocytes concentrate. Method: This study is a cross-sectional observational study as a part of experimental study \\"Efficacy and Risk of Platelet Transfusion\\". Using consecutive sampling method, this study was carried out in UPTD RSUP Dr. Sardjito and Pediatric Hematology-Oncology Ward Estella in April-December 2014. The inclusion criteria was all Pediatric Hematology-Oncology Ward patients who requested platelet to UPTD RSUP Dr. Sardjito. The exclusion criteria was all patients who were diagnosed as suffering disseminated intravascular coagulation, on medication that affect CCI (Amfotericin B, Ciprofloxacin and Vancomycin) and scheduled for bone marrow transplantation or major surgery procedure. Results: There were 51 eligible subjects, 36 subjects were found to receive manually prepared thrombocyte concentrate and 15 subjects received semi-automatically prepared thrombocyte concentrate. All subjects were having similar characteristics between manual and semi-automatic groups. Thrombocyte concentrate had median (IQR) total platelet count of 1,3x1011 (IQR 1,1) and 1,6x1011 (IQR 1,2) in manual and semi-automatic group respectively, which showed no statistically significant difference (p>0,05). Calculation of CCI showed median (IQR) of 17.360 (12.350) and 14.850 (13.250) in manual and semiautomatic group respectively, which showed no statistically significant difference (p>0,05). Conclusion: There are no difference of corrected count increment in subjects receiving manually prepared thrombocyte concentrate compared to subjects receiving semi-automatically prepared thrombocyte concentrate.

Kata Kunci : thrombocyte concentrate, manual, semi-otomatis, corrected count increment


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