PERBEDAAN EKSPRESI INTERLEUKIN-6 JARINGAN KANKER BERDASARKAN LOKASI TUMOR PRIMER ADENOKARSINOMA KOLOREKTAL

NOVI WIJAYANTI SUKIRTO, dr. Neneng Ratnasari, Sp.PD, KGEH

2014 | Tesis | S2 KEDOKTERAN KLINIK/MS-PPDS

Latar belakang Interleukin-6 (IL-6) adalahpleiotropic cytokine yang diproduksiolehsel tumor yang berfungsisebagaifaktorpertumbuhan. Kankerkolorektalmemproduksi IL-6 sehinggapeningkatan IL-6 dimukosa colon merupakansuatutandapertumbuhansel yang berlebihan.Lokasi tumor menjadi salah satu faktor prognostik dalam kanker kolorektal tetapi belum jelas apakah ekspresi yang berlebihandari IL-6 jaringankankerkolorektalterkaiteratdenganlokasi tumor primer . TujuanPenelitian: Untukmengetahuiapakahterdapatperbedaanekspresi IL-6 jaringankankerantara kelompok yang berlokasi di kolon dan rektum pada pasien adenokarsinoma kolorektal di RSUP Dr. Sardjito Yogyakarta Metode: Penelitian dengan desain cross sectionaldan subyek berupa preparat biopsi reseksi tumor adenokarsinoma kolorektal yang memenuhi kriteria inklusi dan esklusi. AnalisisstatistikmenggunakanStatistical Product and Service Solutions (SPSS) 20.0 for Windows. Hasil PenelitianDari 49 sampel penelitian, reratausiapasien 55,75± 12,28 tahun, subyeklaki-laki19 (38,8 %) orang. L okasitumor primer di rektumsebanyak 22 sampel (44,9%), kolonsisikanansebanyak 13 (28,5%) dan kolonsisikirisebanyak 14 (28,6%). Nilaiekspresi IL-6 jaringankanker di kolon sedikit lebihtinggidibandingkan di rektummeskipunsecarastatistiktidakbermakna (0,86 vs 0,80; p = 0,559).Pada analisis subgrup juga tidak didapatkan perbedaan ekspresi IL-6 yang bermakna antara kolon kanan, kiri dan rektum (p= 0,601). Kesimpulan : Tidakterdapatperbedaanekpresi IL-6 jaringan yang signifikanantaralokasi tumor primer di kolondan rectum.

Background Interleukin-6 (IL-6) is a pleiotropic cytokine produced by tumor cell that act as growth factor. Colorectal cancer can produce IL-6 as a consequence there is a raising of IL-6 level in colon mucosa that is showing excessive development of cell. Tumor location is one of prognostic factors in colorectal cancer but it is unclear that increase of IL-6 expression in colorectal cancer is related to primary tumor location. ObjectivesThis reserach is held to find out the difference of tissue expression of IL-6 between which located in colon and rectum in colorectal adenocarcinoma in Sardjito Hospital Yogyakarta Methods : It is a cross sectional study. The subject of this study is the resection preparation of colorectal tissue biopsies from all patients with adenocarcinoma colorectal with tissue samples are sent to the department of Pathology Anatomy Dr. Sardjito between March 2010 and March 2014 that meet the inclusion and exclusion criteria.Statistical analysis was done by Statistical Product and Service Solutions (SPSS) 20.0 for Windows. Results : 49samples ofthis study had been analysed. They consisted of 19male subjects(38.8%) with mean age of 55.75±12.28years old. In all 22samples had rectum cancer (44.9%), 13samples had right colon cancer (28.5%) and14 samples had left colon cancer(28.6%). Level of IL-6 expressionincoloncancertissuewas slightly higher thaninthe rectumalthoughdidn’t differ significant (0,86 vs 0,80; p = 0,559). In thesubgroup analysis, the differences inthe expressionof IL-6 werenot significantlybetweenthe rightcolon, leftandrectum(p =0,601). Conclusion: There is no difference significantly inthe expressionof IL-6 from colorectal adenocarcinoma tissuebetweencolonandrectum

Kata Kunci : interleukin-6 jaringan, adenokarsinoma kolorektal, lokasi tumor