PERBEDAAN KADAR IL-6 BERDASARKAN PENILAIAN FIBROSIS MENURUT SKOR FIB-4 PADA PENDERITA SIROSIS HATI DI RSUP DR.SARDJITO ANTARA MEI-OKTOBER 2014

DR. YULIA SRI SUSANTI ANAS, dr. Neneng Ratnasari, SpPD-KGEH.

2015 | Tesis | SP Ilmu Penyakit Dalam

Latar belakang. Kadar IL-6 meningkat pada pasien hepatitis terutama pada pasien sirosis hati dan karsinoma hepatoseluler (KHS). IL-6 digunakan sebagai penanda progresifitas penyakit hati, dari pada menggunakan metode yang invasif. Salah satu tes diagnosis non invasif untuk menilai fibrosis hati yang sederhana, tersedia, ekonomis, dan akurat adalah skor FIB-4. Tujuan penelitian. Untuk mengetahui perbedaan kadar IL-6 pada penderita sirosis hati berdasarkan kategori fibrosis dengan menggunakan skor FIB-4. Metode dan cara penelitian. Penelitian ini studi potong lintang (cross-sectional study) terhadap pasien sirosis yang diperiksa di Poliklinik Gastroentero- Hepatologi dan Bangsal Penyakit Dalam RSUP Dr.Sardjito Yogyakarta mulai Mei-Oktober 2014, yang memenuhi kriteria inklusi dan eksklusi. Kadar IL-6 terdistribusi normal pada lebih dari 2 kelompok dianalisis dengan uji one way ANOVA. Uji Independent t-test untuk menganalisis data numeric yang terdistribusi normal pada dua kelompok, tidak berpasangan, dan uji Regresi Multivariat, regresi linier untuk uji numeric pada variabel-variabel yang terdistribusi normal, untuk menguji apakah ditemukan variabel-variabel yang mempengaruhi kadar IL-6. Hasil. Didapatkan penderita sirosis terdiri dari 25 orang (78,1%) Pria, 7 orang (21,9%) wanita. Rerata kadar IL-6 berdasarkan kategori I skor FIB-4: 27,78 (SD 1,20), Kategori II skor FIB-4: 27,14 (SD 1,83), kategori III skor FIB-4: 28,09 (SD 3,53), nilai p=0,757, CI 95%. Simpulan. Pada penelitian ini tidak terdapat perbedaan kadar IL-6 yang bermakna secara statistik di antara ketiga kategori skor FIB-4. Kata kunci:

Background. IL-6 levels are elevated in patients with hepatitis, especially in patients with liver cirrhosis and hepatocellular carcinoma (KHS) .il-6 is used as a marker of liver disease progression, rather than using invasive methods. One of the non-invasive diagnostic tests for assessing liver fibrosis are simple, available, economical, and accurate is FIB-4 score. The purpose of the study. To determine differences in the levels of IL-6 in patients with cirrhosis of the liver fibrosis by category using FIB-4 score. Methods and means of research. This study was cross sectional study (crosssectional study) of patients with cirrhosis were examined in the clinic Gastroentero-Hepatology and Internal Medicine Ward DR.Sardjito Hospital Yogyakarta start from May to October 2014, which meets the criteria for inclusion and exclusion. Levels of IL-6 is normally distributed in more than two groups were analyzed by one way ANOVA test. Test Independent t-test to analyze numeric data are normally distributed in two groups, unpaired, and Multivariate Regression testing, linear regression to test the numerical variables were normally distributed, to test whether the variables found to affect the levels of IL-6. Results. Obtained cirrhosis patients consisted of 25 people (78.1%) Male, 7 (21.9%) women. The mean levels of IL-6 based on category I FIB-4 score: 27.78 (SD 1.20), Category II FIB-4 score: 27.14 (SD 1.83), category III FIB-4 score: 28.09 (SD 3.53), p = 0.757, CI 95%. Conclusion. In this study there were no differences in the levels of IL-6 were statistically significant among the three categories of FIB-4 score.

Kata Kunci : IL-6 - skor FIB-4 - Sirosis Hati