TABLET HISAP ASAM MEFENAMAT DENGAN KOMBINASI ZAT PENGIKAT PGA (Pulvis Gummi Arabica) - SUKROSA DALAM FORMULA OPTIMUM MENGGUNAKAN METODE SIMPLEX LATTICE DESIGN

MAYA SYAFRIDA, Prof.Dr. Achmad Fudholi, DEA., Apt

2014 | Skripsi | FARMASI

Tablet hisap biasanya mengandung satu atau lebih kategori berikut, yaitu antiseptik, anastesi lokal, antitusif, analgesik atau dekongestan. Asam mefenamat merupakan analgetik golongan AINS yang sering digunakan, namun yang beredar dipasaran dianggap kurang praktis dan sulit digunakan untuk pasien yang sukar menelan. Pengembangan tablet hisap asam mefenamat diharapkan sebagai alternatif bentuk sediaan yang praktis dan nyaman dalam penggunaan. Penelitian ini bertujuan untuk mendapat formula tablet hisap asam mefenamat yang optimum dengan kombinasi zat pengikat PGA (Pulvis Gummi Arabica) dan sukrosa. Tablet hisap ini dibuat dengan metode granulasi basah. Evaluasi sifat fisik tablet hisap meliputi uji sifat alir, uji keseragaman bobot, uji kekerasan, uji kerapuhan, uji waktu larut, dan uji tanggap rasa. Dibuat 5 formula pada penelitian ini dengan kombinasi PGA banding sukrosa yaitu FI (100%:0%), FII (75%:25%), FIII (50%:50%), FIV (25%:75%) dan FV (0%:100%). Data sifat fisik tablet yang diperoleh diolah dengan menggunakan metode Simplex Lattice Design pada program Design Expert version 9.0.2 untuk mendapat formula optimum. Hasil penelitian yang diperoleh menunjukkan bahwa kombinasi zat pengikat PGA dan sukrosa mempengaruhi sifat fisik granul dan tablet hisap asam mefenamat. Formula optimum tablet hisap asam mefenamat diperoleh pada kombinasi PGA dan sukrosa masing masing 12,31 % dan 87,69% terhadap konsentrasi zat pengikat dalam tablet.

A lozenge is mostly contained one or more medicines, like antiseptic, local anesthetic, antitussive, analgesic, and decongestant. Mefenamic acid is categorized as NSAID (non-steroidal anti-inflammatory drug) analgesic, which is quite well-known for medical usage in a tablet form, but this mefenamic acid is not easily consumed for people that have problem in swallow things. A development of mefenamic acid in a lozenge form will make this NSAID is practically consume. The purpose of this research is to find an optimum formula of mefenamic acid lozenge, by combining PGA (Pulvis Gummi Arabica) with sucrose. Wet granulation method is applied in making this lozenge. The evaluation of physical characteristic includes flow properties test, uniformity of weight test, hardness test, fragility test, dissolution test, and taste test. Five formulas is created in this research with the combination of PGA equal sucrose; F1 (100% : 0%), FII (5% : 25%), FIII (50% : 50%), FIV(25% : 75%), and FV (0% : 100%). To find the optimum formula, the obtained data of the physical characteristic will be processed, by using Simplex Lattice Design method (Design Expert Program version 9.0.2). The result of this research shows that a combination of PGA and sucrose affects the physical characteristic of the granule and the mefenamic acid lozenge. The optimum formula of mefenamic acid lozenge is a combination between 12,31% of PGA and 87,69% of sucrose, against the concentration of the binder in lozenge itself.

Kata Kunci : Asam mefenamat, tablet hisap, PGA, sukrosa, Simplex lattice design