FREQUENCY OF OUTPATIENT UNDERGOING CHEMOTHERAPY HAVING HIGH RISK OF VENOUS THROMBOEMBOLISM (KHORANA SCORE) AND SUGGESTED CHOICE OF PROPHYLAXIS IN TULIP DEPARTMENT AT DR SARDJITO HOSPITAL

MUHAMMAD ARIANSYAH H.S., dr.Johan Kurnianda, Sp.PD-KHOM ; dr.Mardiah Suci Hardianti, Sp.PD,Ph.D ; dr.Ibnu Purwanto, Sp.PD-KHOM

2014 | Skripsi | PENDIDIKAN DOKTER

BACKGROUND: Venous thromboembolism (VTE) is a condition when clot or thrombi developed in the vein. It related to the two condition, deep vein thrombosis (DVT) and pulmonary embolism (PE). This condition can increase the mortality and morbidity of the patient. Cancer can increase VTE occurrences by 5 times higher than noncancer patient, and chemotherapy can increase the risk 6,5 times higher compare who didn’t receive. VTE can be prevent by do prophylaxis intervention consist of medical and mechanical prophylaxis OBJECTIVE: To find out the frequency of chemotherapy patients which have low risk of VTE, Intermediate risk VTE, and high risk of VTE and suggested choice of prophylaxis based on ASCO guideline for treat cancer patients who undergoing chemotherapy with intermediate risk for VTE and high risk for VTE. METHOD: Data from 280 patients medical record were taken from tulip department at RSUP DR Sardjito and analyzed using Khorana score and to know the frequency of each VTE risks RESULT: From 280 patient, 25 patients are categorized low risk of VTE (8,93%), 228 patients are categorized intermediate risk of VTE (81,43%), and 27 patients categorized as high risk of VTE (9,64%) CONCLUSION: Among outpatient, the intermediate risk of VTE is the most common and the use of prophylaxis we can choose pharmacological prophylaxis based on the bleeding risk of the patients but with highly selected criteria KEYWORDS: Venous thromboembolism, cancer, chemotherapy, Khorana score, prophylaxis

BACKGROUND: Venous thromboembolism (VTE) is a condition when clot or thrombi developed in the vein. It related to the two condition, deep vein thrombosis (DVT) and pulmonary embolism (PE). This condition can increase the mortality and morbidity of the patient. Cancer can increase VTE occurrences by 5 times higher than noncancer patient, and chemotherapy can increase the risk 6,5 times higher compare who didn’t receive. VTE can be prevent by do prophylaxis intervention consist of medical and mechanical prophylaxis OBJECTIVE: To find out the frequency of chemotherapy patients which have low risk of VTE, Intermediate risk VTE, and high risk of VTE and suggested choice of prophylaxis based on ASCO guideline for treat cancer patients who undergoing chemotherapy with intermediate risk for VTE and high risk for VTE. METHOD: Data from 280 patients medical record were taken from tulip department at RSUP DR Sardjito and analyzed using Khorana score and to know the frequency of each VTE risks RESULT: From 280 patient, 25 patients are categorized low risk of VTE (8,93%), 228 patients are categorized intermediate risk of VTE (81,43%), and 27 patients categorized as high risk of VTE (9,64%) CONCLUSION: Among outpatient, the intermediate risk of VTE is the most common and the use of prophylaxis we can choose pharmacological prophylaxis based on the bleeding risk of the patients but with highly selected criteria KEYWORDS: Venous thromboembolism, cancer, chemotherapy, Khorana score, prophylaxis

Kata Kunci : Venous thromboembolism, cancer, chemotherapy, Khorana score, prophylaxis