NANOPARTIKEL ALGINAT-KITOSAN SEBAGAI SISTEM LEPAS LAMBAT KURKUMIN

AGENG TRISNA SPP, Dr. Dwi Siswanta, M. Eng.

2014 | Tesis | S2 Ilmu Kimia

Telah dilakukan preparasi material lepas lambat kurkumin dengan menggunakan alginat dan kitosan serta evaluasi sifat pelepasannya. Nanopartikel dibuat dengan metode pre-gelasi ionik dari inti alginat dan dilanjutkan kompleksasi polielektrolit kitosan. Kurkumin dipilih sebagai model obat. Karakterisasi permukaan, morfologi dan struktur nanopartikel diidentifikasi menggunakan scanning electron microscope (SEM), transmission electron microscope (TEM) dan spektra FTIR. Optimasi dilakukan terhadap konsentrasi polimer dan kalsium. Diameter nanopartikel yang dihasilkan yaitu 51 dan 90 nm mampu melewati kapiler serta mampu menghasilkan efisiensi enkapsulasi obat yang tinggi dalam rentang antara 65-85%. Pelepasan terkontrol kurkumin dipelajari secara in vitro dalam media phosphate buffer saline (PBS) pada pH 7,4. Berdasarkan hasil yang diperoleh, nanopartikel mengindikasikan bahwa berpotensi sebagai sistem lepas lambat karena dapat tinggal dalam waktu yang lama di dalam aliran darah serta meningkatkan kelarutan obat. Kata kunci: lepas lambat, pre-gelasi, nanopartikel, kurkumin

Preparation of a curcumin slow release materials using alginate and chitosan and evaluation of their release properties have been done. The nanoparticles were prepared by ionotropic pre-gelation of alginate core and followed by polyelectrolyte complexation of chitosan. Curcumin was chosen as a model drug. Surface area, morphology and structure characterization of nanoparticles were investigated by scanning electron microscope (SEM), transmission electron microscope (TEM) and fourier transform infrared spectra (FTIR). The optimization was done in term of calcium and polymer concentration. The diameter of the nanoparticles was about 51 and 90 nm, they were suitable for uptake in capillary due to their nanosize range and high drug encapsulation efficiency was achieved ranging from 65-85%. Studies in vitro of the controlled release of curcumin were investigated in phosphate buffer saline (PBS) at pH 7.4. The results indicated that nanoparticles presented potential as a slow release system because they could stay long time into bloodstream and improve solubility of the drug. Key words: slow release, pre-gelation, nanoparticles, curcumin

Kata Kunci : lepas lambat, pre-gelasi, nanopartikel, kurkumin