OPTIMASI FORMULA TABLET HISAP ASAM MEFENAMAT MENGGUNAKAN KOMBINASI ZAT PENGIKAT AMILUM-PGA (Pulvis Gummi Arabica)-SUKROSA BERDASARKAN METODE SIMPLEX LATTICE DESIGN

DYAH TRIANAS PUTRI, Prof. Dr. Achmad Fudholi, DEA., Apt.

2014 | Skripsi | FARMASI

Asam mefenamat digunakan sebagai antiinflamasi yang diberikan secara oral dan tersedia dalam bentuk sediaan tablet dan kapsul. Pada beberapa pasien mengalami kesukaran dalam menelan tablet asam mefenamat dan kurang nyaman akan rasanya yang pahit. Tablet hisap asam mefenamat diharapkan mampu mengatasi permasalahan yang timbul. Penelitian ini bertujuan untuk mengetahui pengaruh penggunaan zat pengikat amilum, PGA dan sukrosa terhadap sifat fisik tablet hisap asam mefenamat. Tujuh formula dibuat dengan kombinasi amilum : PGA : sukrosa yaitu FI (100%:0%:0%), FII (0%:100%:0%), FIII (0%:0%):100%, FIV (50%:50%:0%), FV (0%:50%:50%), FVI (50%:0%:50% dan FVII (33,3%:33,3%:33,3%). Tablet hisap dibuat dengan metode granulasi basah. Evaluasi sifat fisik tablet hisap meliputi uji keseragaman bobot, uji kekerasan, uji kerapuhan, uji waktu larut, dan uji tanggap rasa. Data sifat fisik tablet yang diperoleh diolah dengan menggunakan metode Simplex Lattice Design pada program Design Expert version 7.1.5. Hasil yang diperoleh menunjukkan bahwa zat pengikat PGA (Pulvis Gummi Arabica) akan meningkatkan kekerasan tablet hisap asam mefenamat. Campuran ketiga zat pengikat akan menurunkan nilai kerapuhan dan memberikan rasa yang enak pada tablet hisap dan amilum dapat mempercepat waktu larut tablet hisap asam mefenamat. Kombinasi amilum : PGA (Pulvis Gummi Arabica) : sukrosa pada perbandingan 50% : 50% : 0% berada pada daerah optimum dengan nilai desirability tertinggi yang memberikan sifat fisik optimum pada tablet hisap asam mefenamat.

Mefenamic acid is indicated as an anti-inflammatory drug that administered orally in tablet and capsule dosage form. But for some patients with inabilities to swallow, it is inconvenience and give a bitter taste. Mefenamic acid troches is the solution for this problem. This research aims to identified the effect of starch, PGA (Pulvis Gummi Arabica) and sucrose as binding agents on physical properties of mefenamic acid troches. Seven combinations of starch : PGA : sucrose were made, which are FI (100%:0%:0%), FII (0%:100%:0%), FIII (0%:0%):100%, FIV (50%:50%:0%), FV (0%:50%:50%), FVI (50%:0%:50%, and FVII (33,3%:33,3%:33,3%). Wet granulation was method was chosen to produce the troches. The evaluation of physical properties of mefenamic acid troches on this research includes weight uniformity test, hardness test, friability test, late time test, and responsive taste test. The data then analyzed with Simplex Lattice Design method with Design Expert version 7.1.5. The results showed that PGA (Pulvis Gummi Arabica) would increase the hardness of the mefenamic acid troches. The mixing of the three binding agents would decrease the value of the troches’ friability and give a good taste for the troches and the starch could accelerate the late time of mefenamic acid troches. The combination of starch : PGA (Pulvis Gummi Arabica) : sucrose with the ratio 50% : 50% : 0% were placed in optimum area with the highest desirability value that gave optimum physical properties of mefenamic acid.

Kata Kunci : Asam mefenamat, tablet hisap, amilum, PGA (Pulvis Gummi Arabica), sukrosa