HUBUNGAN ASUPAN ANTIOSKIDAN DENGAN FREKUENSI SERANGAN ASMA PADA PASIEN RAWAT JALAN DI POLIKILINIK ASMA RSUP PERSAHABATAN JAKARTA

JOANA RISMADHANTY, Dr. Budi Antariksa, Sp.P,

2014 | Skripsi | GIZI KESEHATAN

Asma merupakan kelainan saluran pernafasan yang berkaitan dengan meningkatnya Reactive Oxygen Species (ROS). Asma menyebabkan perubahan status serum antioksidan yang disebabkan peningkatan oksidan (Nadeem, 2008). Rendahnya asupan antioksidan dapat memicu terjadinya inflamasi karena minimnya pertahan/proteksi terhadap ROS Tujuan Penelitian : Tujuan dari penelitian ini adalah untuk mengetahui hubungan antara asupan antioksidan (Vitamin A, Vitamin C, Vitamin E) dengan frekuensi serangan asma pasien di Poliklinik Paru RSUP Persahabatan. Metode : Penelitian cross-sectional ini diikuti delapan puluh sembilan pasien asma RS Persahabtan yang sedang menjalani perawatan. Responden dipilih melalui metode purposive sampling. Pengumpulan data diperoleh melalui data faktor resiko asma untuk mengetahui penyebab asma, asthma control test untuk mengetahui frekuensi serangan asma dan SQ-FFQ untuk mengetahui asupan antioksidan (vitamin A, vitamin C, dan Vitamin E) Hasil : Rata-rata asupan vitamin A lebih besar pada kelompok asma tidak terkontrol daripada asma terkontrol. Sedangkan rata-rata asupan vitamin C dan vitamin E lebih tinggi pada pasien asma terkontrol. Tidak ada hubungan signifikan antara asupan Antioksidan (Vitamin A, Vitamin C, dan Vitamin E) dengan frekuensi serangan asma (p>0,05).

Asthma is airways disorder that associated with an increased of generation Reactive Oxygen Species (ROS). ROS leads to lung damge caused by direct effect of oxidative stress on epthileal cell and shedding cell that linked to pathogenesis of asthma, which induces airway hiperreativity through histamine release by mast cell and mucus secretion. Low antioxidant intake may play role in response inflammatory because of deficits antioxidant defense/ protection against ROS . Objectives : the aim of this research to identify wether antioxidant intake is associated with asthma attack frequency in adults. Methods : Cross sectional study of 89 asthmatic who attended outpatient asthma and COPD clinic at RS Persahabatan which taken using purposive sampling. The data were collected by asthma control test, risk asthma questionnaire and semi-quantitative questionnaire and were analyzied using chi-square test and spearman correlation. Result : Uncontrolled asthmatics had higher intake vitamin A than controlled asthma patient. But on the contarary, intake vitamin C and E were higher in uncontrolled asthmatics. There was no significant difference in dietary intake of antioxidant (vitamin A, C and E) betweem uncontrolled asthmatic and controlled asthmatic (p>0,05). Conclusion : These results didn’t support the hypothesis that antioxidant intake (vitamin A, C and E) had positive association with asthma attack frequency

Kata Kunci : Vitamin A, Vitamin C, Vitamin E, Asma