Model pengobatan filariasis malayi dengan Diethyl Carbamazine Citrate (DEC) dosis bertahap di Kabupaten Tabalong Kalsel tahun 2001

ANORITAL, Prof.dr. Soesanto Tj., MCommH.,MSc.,PhD

2001 | Tesis | S2 Ilmu Kedokteran Klinis

Ministry of Health policy on filariasis eradication is mass treatment with diethyl carbamazine citrate (DEC) low dose as long as I0 months (40 week$. In the ,field, the policy faces many constraints such as a high drop out rate because of the long time for treatment. The aim of the study is to test the eficacy of a Jilariasis treatment model with DEC in phased doses in 3 months in a non program area. Tabalong regency in South of Kalimantan is selected as study area because it is a non program area with an estimuted high prevalence rate of filariasis where elephantiasis cases have been jound. iype qf study is u liandomised Control Trial - Yroi,vpective liandomised Open Blinded end point Evaluation (RCT PROBE). In the trial the phased dose is given to the intervention group while the control group is treated with a low dose. This trial is performed to know the decreased of microfilariae in peripheral blood in research subjects with have treatment by phased dose compared with low dose. Yhused dose is given DEC tablets to research subject at first month 4 times given on low dose (100 mg for adult and 50 mg for children), second month 8 times given on low dose, und third month 6 times given on standard dose (6 mg/kg body weight). Low dose is given DEC tablets to research subject at first month 4 times given on low dose, second month 4 times given on low dose, and third month 8 times given on low dose. Before the trial, a microfilariae survey of people filariasis endemic village is undertaken. Microjiluriue survey was performed in 905 people. Result of survey found 46 microfilaremia cases .(5.08%) wich will be the research subjects. The 46 microfilariae cuses were rundomized into two groups: an intervention with phased dose and control group with low dose. A total of 4 research subjects have droped out and only 42 research subjects can be analyzed. Result of the research found a sign@ant decreased of micrcfilariue both .for the intervention group (phased dose) and the control group (low dose) after I and 3 months treatment (p 0.05). There wus also positive correlation between total dose with microfiluriae decrease percentage after 3 month treatment in the treatment as well as the control group. . The study suggest that muss treatment offilariasis should be undertaken with u phased dose because if is shorter and saves time long as 3 months, side eflects of treatment ure not dflerent with low dose, and minimal total dose 2,494 mg will be reached with 99.78% decrease in microfilariae

Ministry of Health policy on filariasis eradication is mass treatment with diethyl carbamazine citrate (DEC) low dose as long as I0 months (40 week$. In the ,field, the policy faces many constraints such as a high drop out rate because of the long time for treatment. The aim of the study is to test the eficacy of a Jilariasis treatment model with DEC in phased doses in 3 months in a non program area. Tabalong regency in South of Kalimantan is selected as study area because it is a non program area with an estimuted high prevalence rate of filariasis where elephantiasis cases have been jound. iype qf study is u liandomised Control Trial - Yroi,vpective liandomised Open Blinded end point Evaluation (RCT PROBE). In the trial the phased dose is given to the intervention group while the control group is treated with a low dose. This trial is performed to know the decreased of microfilariae in peripheral blood in research subjects with have treatment by phased dose compared with low dose. Yhused dose is given DEC tablets to research subject at first month 4 times given on low dose (100 mg for adult and 50 mg for children), second month 8 times given on low dose, und third month 6 times given on standard dose (6 mg/kg body weight). Low dose is given DEC tablets to research subject at first month 4 times given on low dose, second month 4 times given on low dose, and third month 8 times given on low dose. Before the trial, a microfilariae survey of people filariasis endemic village is undertaken. Microjiluriue survey was performed in 905 people. Result of survey found 46 microfilaremia cases .(5.08%) wich will be the research subjects. The 46 microfilariae cuses were rundomized into two groups: an intervention with phased dose and control group with low dose. A total of 4 research subjects have droped out and only 42 research subjects can be analyzed. Result of the research found a sign@ant decreased of micrcfilariue both .for the intervention group (phased dose) and the control group (low dose) after I and 3 months treatment (p 0.05). There wus also positive correlation between total dose with microfiluriae decrease percentage after 3 month treatment in the treatment as well as the control group. . The study suggest that muss treatment offilariasis should be undertaken with u phased dose because if is shorter and saves time long as 3 months, side eflects of treatment ure not dflerent with low dose, and minimal total dose 2,494 mg will be reached with 99.78% decrease in microfilariae

Kata Kunci : Epidemiologi Klinik,Pengobatan Filariasis Malayi,DEC,Dosis Bertahap