CORRELATION BETWEEN TRANSEPIDERMAL WATER LOSS (TEWL) ON NON-LESIONAL SKIN AREA AND CLINICAL SEVERITY OF ATOPIC DERMATITIS

ADELLIA DIAN PERMATASARI, dr. Niken Trisnowati, M.Sc., Sp.KK.

2014 | Skripsi | PENDIDIKAN DOKTER

Background : Atopic dermatitis usually develops in patients with an individual or family history of allergic diseases, and is characterized by chronic relapsing inflammation seen especially in childhood, associated with IgE hyperproduction and precipitation by environmental factors. However, the exact etiology has been unclear, and so far there is no research done in Yogyakarta to know whether transepidermal water loss on non-lesional skin area will affect the severity of atopic dermatitis or not. Objective : The objective of the study is to know whether transepidermal water loss on non-lesional skin area will affect the severity of atopic dermatitis or not (measured by Objective SCORAD index in the non lesion area). Methodology : The measurement of Transepidermal Water Loss (TEWL) on the non-lesional skin area was done by using TEWAmeter, while the severity of atopic dermatitis was measured by objective SCORAD. And then, the correlation between these two parameters were analyzed by Spearman's rho Correlation Test. The subjects are atopic dermatitis patients at Dermatovenerology Clinic dr. Sardjito Hospital, Yogyakarta, Indonesia from April-September 2012. Result : Statistic test using Spearman's rho Correlation Test shows that there is no correlation between transepidermal water loss on non-lesional skin area with the clinical severity of atopic dermatitis. Summary : Transepidermal water loss on non-lesional skin area is not correlated with clinical severity of atopic dermatitis. Keyword : severity of atopic dermatitis, objective SCORAD index, transepidermal water loss.

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Kata Kunci : severity of atopic dermatitis, objective SCORAD index, transepidermal water loss.