HUBUNGAN CIRI FISIKOBIOLOGIK KULIT DENGAN PERSEPSI DIRI KULIT SENSITIF Kajian dalam Transepidermal Water Loss, Hidrasi Kulit, dan Kadar Sebum

Syahfori widiyani, Dr. dr.Sunardi Radiono, Sp.KK(K)

2014 | Tesis | S2 Ked.Klinik/MS-PPDS

LatarBelakang Keluhan atau istilah kulit sensitif digunakan oleh individu yang menilai bahwa kulitnya kurang bertoleransi terhadap produk kosmetik yang digunakan dan terhadap faktor lingkungan dibandingkan populasi umum. Jumlah individu yang mengeluhkan kulit sensitif semakin meningkat, biasanya di wajah, dan dikeluhkan oleh wanita di negara industri pada berbagai etnik.Gejala kulit sensitif adalah sensasi ‘cekit-cekit’ seperti tersengat, panas, dan gatal, dengan atau tanpa tanda klinis iritasi.Etiologi kulit sensitif belum diketahui, namun dipercaya merupakan hasil peningkatan permeabilitas stratum korneum atau percepatan respon saraf.Terdapat kontroversi patogenesis kulit sensitif, apakah ada masalah pada barier kulit, atau hanya gangguan neurosensorik, atau adanya penyakit kulit lain. Masalah barier kulit dapat diperiksa dengan ciri fisiko biologik kulit. Tujuanuntukmengetahuihubunganciri fisikobiologik kulit dengan persepsi diri kulit sensitif (PDKS)dalam kajian transpidermal water loss, hidrasi kulit, dan kadar sebum. Metodekasuskontroluntukmengetahuihubungantranspidermal water loss (TEWL), hidrasi kulit, dan kadar sebum dengan persepsi diri kulit sensitif. Hasiljumlahsubyekmasing-masingadalah50.Pada semua kelompok usia, rerata nilai TEWLkelompok PDKS dankontrol berturut-turutadalah8,581 ± 3,033 gr/m2/jamdan8,97 ± 3,4 gr/m2/jam; rerata hidrasi kulitadalah41,31 ± 11,65 dan 39,055 ± 13,19; reratakadar sebumadalah54,97 ± 28,65 dan 52,14 ± 33,95 μg/cm2 (p>0,005). Tidak terdapat perbedaan rerata nilai TEWLdan kadar sebum pada tiap kelompok usia PDKS. Terdapat perbedaan bermakna rerata hidrasi kulit pada kelompok usia <25 tahun dengan 26-35 tahun (IK 95% 0,534-21,277; p=0,034).Nilai korelasi antara transpidermal water loss, hidrasi kulit, dan kadar sebum dengan PDKS berturut adalah 0,034, -,005, -0,073 (p>0,05). Kesimpulantidak terdapat hubungan antara transpidermal water loss, hidrasi kulit, kadar sebum denganpersepsi diri kulit sensitif

Background Sensitive skin complaint is used by individuals who feel that their skin is less tolerant of both cosmetic products used and the environmental factors, compared to the general population. The number of individuals who complained of sensitive skin usually on the face, increase lately and particularly werecomplained by women in industrialized countries at different ethnic. The skin sensitive symptoms are usually marked with the sensation of 'small pricking' like tingling, heat, and itching, with or without clinical signs of skin irritation. The etiology of sensitive skin is unknown, but it is believed that it comes from the increase of the stratum corneum permeability or the acceleration of the neural response.The pathogenesis of sensitive skin is still debatable whether there is a problem on the skin barrier, neurosensorydisorder, or the presence of other skin diseases. Problem of skin barrier can be measured with the physicobiologic skin features. Objectivetodetermine the association between physicobiologic skin features in terms of transpidermal water loss, skin hydration, sebum levels and selfperceptionof sensitive skin (SPSS). Metode case control design was used to determine the relationship between transpidermal water loss (TEWL), skin hydration, levels of sebum and sensitive skin self-perceptions. Result of the amount of each subject is 50 in all age groups, the mean TEWL value SPSS and control groups were 8.581 ± 3.033 and 8.97 ± 3.4 gr/m2/hr, the mean skin hydration was 41.31 ± 11.65 and 39.055 ± 13.19; the mean sebum levels were 54.97 ± 28.65 and 52.14 ± 33.95 μg/cm2 (p > 0.005), respectively. There was no difference in the mean value of TEWL and sebum levels in each age group of SPSS. There are significant differences in the mean skin hydration between of the age groups <25 yearwith 26-35 year(95% CI 0.534 to 21.277, p=0.034). Correlationvaluebetween transpidermalwater loss, skin hydration, sebum levels with SPSS was 0.034, -0.005, -0.073(p>0.05). Conclusion there is no correlation between transpidermal water loss, skin hydration, sebum levels and self-perception of sensitive skin.

Kata Kunci : skor Lok Index, asam hialuronik, sirosis hati, hepatitis kronik