CORRELATION BETWEEN DIAGNOSIS DELAY AND RISK STRATIFICATION OF B-PRECURSOR ACUTE LYMPHOBLASTIC LEUKEMIA IN CHILDREN
MICHAEL DWINATA, dr. Eddy Supriyadi, Sp.A(K), Ph.D
2014 | Skripsi | PENDIDIKAN DOKTER-
Background : B-precursor ALL patients are classified to risk-based stratification to determine the treatment. Generally, delay correlates with progression of disease and a more advanced stage of cancer is associated with worse outcome. In this research, the possible correlation between diagnosis delay with risk stratification of pediatric B-precursor ALL patient is assessed. Objective : to understand the correlation of diagnosis delay with the risk stratification of B-precursor ALL in children. Method : This is an observational study, using retrospective design by referring to medical record of B-precursor ALL patient from year 2008-2011 in Pediatric Department, RSUP Dr. Sardjito, Yogyakarta Result : Among 58 medical record analyzed, the mean of delay was 58 days. Analysis using mean as cut-off showed no significant correlation (p= 0,3), but the OR was 1.99 (CI : 0,55-7,22). Summary : There is 2 times increased risk to become high risk ALL after 58 days of delay. Further study with bigger sample size should be conducted to confirm the result
Kata Kunci : pediatric Pre-B ALL, risk stratification, diagnosis delay, acute lymphoblastic leukemia
