PROFIL RESIPIEN TRANSFUSI PRODUK THROMBOPHERESIS DI RSUP SARDJITO, YOGYAKARTA

IKA SAFIRA, Prof. Dr. dr. Teguh Aryandono, Sp.B(K)Onk

2014 | Skripsi | PENDIDIKAN DOKTER

LATAR BELAKANG : Thrombopheresis merupakan upaya untuk mengambil trombosit dan mengembalikan komponen darah lain ke tubuh subjek dengan jumlah trombosit per unitnya 4-6 kali metode BC atau PRP whole blood. Meskipun demikian, prosedur thrombopheresis masih jarang dilakukan di Indonesia karena berbiaya yang tinggi dan tidak banyak donor apheresis yang tersedia karena prosedur lebih berat dibandingkan donor whole blood. Karena masih jarang dilakukan, efikasi transfusi thrombopheresis pada resipien belum banyak diketahui. Hal ini mendorong perlunya melihat profil resipien transfusi thrombopheresis dan korelasinya dengan efikasi transfusi trombosit. TUJUAN : Penelitian ini bertujuan mengetahui profil resipien transfusi thrombopheresis di RSUP Sardjito dan korelasinya dengan efikasi transfusi. METODE : Penelitian ini menggunakan metode potong lintang (cross-sectional), deskriptif-analitik. Penelitian dilaksanakan di Unit Pelayanan Transfusi Darah (UPTD) dan Instalasi Rekam Medik RSUP Sardjito. Subjek penelitian adalah resipien thrombopheresis RSUP Sardjito pada bulan Agustus 2012 hingga Januari 2013. HASIL : Hasil analisis menunjukkan rerata jumlah trombosit pre-transfusi sebesar 20 x 103/μL dengan nilai tengah peningkatan jumlah trombosit 50 x 103/μL di mana resipien wanita memiliki peningkatan jumlah trombosit lebih tinggi. Tidak terdapat hubungan antara yield dengan peningkatan jumlah trombosit pasca transfusi pada resipien (p.>0,05). Resipien berumur 20-40 tahun memiliki peningkatan jumlah trombosit tertinggi. Namun, tidak ditemukan hubungan antara umur dengan peningkatan jumlah trombosit pasca transfusi (p.>0,05). Rerata peningkatan jumlah trombosit pasca transfusi tertinggi pada resipien pasien berdiagnosis bukan keganasan. Sampai saat penelitian berlangsung, belum terdapat laporan efek samping pada resipien pasca transfusi. KESIMPULAN : Tidak terdapat hubungan signifikan antara usia, jenis kelamin, dan diagnosis resipien, serta yield yang ditransfusikan dengan efikasi transfusi. Tidak ditemukan efek samping pasca transfusi pada resipien.

BACKGROUND : Thrombopheresis is an attempt to take thrombocyte and restore other blood component to subject, in which number of thrombocytes are 4-6 times the BC method of whole blood or PRP per unit. Nevertheless, the procedure is rarely performed in Indonesia because of the high cost and not many donors are available since its procedure is heavier than whole-blood donors. Because of its rareness, efficacy of thrombopheresis in recipient has not been known. This prompted the need to investigate the profile of thrombopheresis recipient and its correlation with efficacy of thrombocyte transfusion. PURPOSE : This study aims to identify the profile of thrombopheresis transfusion recipient at RSUP Sardjito and its correlation with efficacy of transfusion. METHOD : This study is a cross-sectional (cross-sectional), descriptive-analytic study. The experiment was conducted at the Blood Transfusion Service Unit (UPTD) and Medical Records Center at RSUP Sardjito. Subjects were thrombopheresis recipients at Sardjito Hospital in August 2012 to January 2013. RESULT : The analysis result showed pre-transfusion thrombocytes count mean of 20 x 103/μL with a median value increase in the number of thrombocytes 50 x 103/μL, where women recipients have a higher post-transfusion thrombocyte count increment. There was no relationship between yield and recipient post-transfusion thrombocyte count increment(p.> 0.05). Recipients aged 20-40 years had the highest thrombocyte count increment. However, no relationship was found between age and the post-transfusion thrombocyte count increment(p.> 0.05). The mean post-transfusion thrombocyte count increment was highest in patients diagnosed without malignancy. There has been no reports of side effects in post-transfusion recipients. CONCLUSION : There was no significant relationship between age, sex, and diagnosis of the recipient, as well as yield transfused with transfusion efficacy. No adverse reactions in recipient was reported after the thrombopheresis transfusion.

Kata Kunci : thrombopheresis, trombositopenia, efikasi transfusi trombosit, pasien keganasan, efek samping transfusi thrombopheresis