PROFIL DONASI THROMBOPHERESIS DI UNIT PELAYANAN TRANSFUSI DARAH RSUP DR SARDJITO YOGYAKARTA

ADITYA WICAKSANA, dr. Teguh Triyono, M.Kes., Sp.PK(K).

2013 | Skripsi | PENDIDIKAN DOKTER

Latar Belakang: Setiap tahun, berjuta-juta kehidupan manusia di bumi terselamatkan oleh kegiatan transfusi darah. Agar didapatkan hasil transfusi darah yang optimal maka harus ada penyediaan darah yang aman dan diperlukan suatu alur kerja yang berkesinambungan, sehingga dapat menunjang pengobatan penderita. Saat ini transfusi cenderung memakai komponen darah yang sesuai dengan kebutuhan. Transfusi trombosit menjadi suatu hal yang penting untuk mencegah mortalitas dan morbiditas pada pasien trombositopenik dengan risiko perdarahan yang tinggi. Yield produk thrombopheresis, dipengaruhi oleh faktor-faktor baik dari aspek pendonor maupun prosedur. Kualitas yield produk thrombopheresis yang baik akan berimbas kepada kenaikan trombosit pasca transfusi dan perbaikan kondisi klinis resipien. Oleh karena itu, perlu dikaji lebih lanjut mengenai profil donasi thrombopheresis. Tujuan: Penelitian ini bertujuan untuk menganalisis faktor-faktor dari aspek pendonor dan prosedur terhadap kualitas produk donasi thrombopheresis. Metode: Penelitian ini merupakan penelitian deskriptif analitik dengan 44 sampel penelitian yang didapat dari data donasi dan data rekam medis, untuk kemudian dianalisis hubungannya terhadap kualitas produk donasi dan efikasi transfusi thrombopheresis. Hasil: Pada 44 sampel penelitian didapatkan bahwa jumlah trombosit pra donasi dan volume produk thrombopheresis berkorelasi positif dengan yield produk thrombopheresis. Yield produk thrombopheresis tidak berkorelasi dengan efikasi transfusi. Kesimpulan: Jumlah trombosit pra donasi dari aspek pendonor mempengaruhi kualitas produk thrombopheresis. Volume produk thrombopheresis dari aspek prosedur mempengaruhi yield produk thrombopheresis. Meskipun demikian, yield produk thrombopheresis tidak berkorelasi dengan kenaikan shitung trombosit pasca transfusi

Background: Every year, millions of people all over the world are saved by blood transfusion. To obtain an optimal result of blood transfusion, it is important to provide safe blood transfusion which is in accordance with the standard and comprehensive workflow, thus increasing the quality of care. Nowadays, blood transfusion uses specific blood component that meet certain requirements. Thrombocyte transfusions are essential to prevent morbidity and mortality in patients who are severely thrombocytopenic and are at risk of spontaneous bleeding. Quality of thrombopheresis product donation in terms of yield, is influenced by aspects from both factors, donor and procedure. A good quality of thrombopheresis product donation will impact the efficacy and thrombocyte recovery of the recipient, thus improving the clinical state. Therefore, it is necessary to elaborate on the profile of thrombopheresis donation. Objective: The aim of this study is to analyze factors from both donor and procedure that affect the quality of thrombopheresis product donation. Methods: Using descriptive analytic study method, 44 samples gathered from data of blood donation and medical record were analyzed to find the correlation between the quality of thrombopheresis product donation in terms of yield and the efficacy of transfusion in terms of absolute count increment. Results: A total of 44 samples were studied. The study showed that pre donation thrombocyte count and volume of thrombopheresis product correlated positively to the yield of thrombopheresis. These results were statistically significant (p<0,05). Yield of thrombopheresis was not correlated to the post transfusion thrombocyte count. Conclusion: Pre donation thrombocyte count and product volume of thrombopheresis influence the yield of thrombopheresis. However, the yield itself has no influence to the post donation thrombocyte count.

Kata Kunci : jumlah trombosit pra donasi, volume produk thrombopheresis, yield produk thrombopheresis, thrombopheresis.