STUDI PELEPASAN KURKUMIN MENGGUNAKAN FILM KITOSAN/KARAGINAN TERTAUT SILANG GLUTARALDEHID

ARINTINA SRI MARADEWI, Dr. Dwi Siswanta, M. Eng

2013 | Skripsi | KIMIA

Telah dilakukan penelitian mengenai studi pelepasan kurkumin menggunakan film kitosan/karaginan tertaut silang glutaraldehid untuk menentukan efektivitas film dalam melepaskan kurkumin di dalam larutan buffer pH 7. Komposisi dari komponen film yang mempengaruhi pelepasan kurkumin telah dipelajari, termasuk kitosan, karaginan, Tween 80 dan Span 80. Pengaruh konsentrasi kurkumin yang termuat dalam film terhadap kecepatan pelepasan film juga dipelajari. Film dibuat dengan cara memadukan larutan kitosan dalam 1% asam asetat dengan larutan karaginan dalam akuades, kemudian ditambahkan glutaraldehid sebagai agen taut silang dengan kitosan. Film yang dihasilkan dikarakterisasi dengan FT-IR. Studi pelepasan kurkumin dilakukan dengan cara membenamkan film di dalam larutan buffer selama 6 jam. Konsentrasi kurkumin yang terlepas ditentukan secara spektrofotometri. Kinetika pelepasan kurkumin dianalisis dengan persamaan Korsmeyer-Peppas. Hasil penelitian menunjukkan bahwa komposisi optimal film adalah 10,2% kitosan, 61,2% karaginan, 20,4% Tween 80 dan 8,2% Span 80 yang memberikan optimum pemuatan kurkumin sebesar 20,4 mg/g film. Konstanta kinetik Korsmeyer-Peppas untuk film ini yaitu 27,5 menit-0,1. Pelepasan kurkumin dalam film maksimum dicapai pada 44,5% dalam 6 jam.

A study on the release of curcumin using glutaraldehyde-crosslinked chitosan/carrageenan film had been conducted in order to determine the effectiveness of the film to release curcumin in pH 7 buffer solution. The composition of the film components that affected the release curcumin including chitosan, carrageenan, Tween 80 and Span 80 were studied. The effect of the concentration curcumin loaded in the film on the rate of the curcumin released was also studied . Film was prepared by mixing the 1% acetic acid solution of chitosan and the aqueous solution of carrageenan, then adding glutaraldehyde as crosslinking agent for chitosan. The products were characterized using FT-IR spectrophotometer. Study on the release of curcumin was accomplished by immersing film in a buffer solution for 6 hours. The concentration of curcumin were determined spectrophotometrically. Curcumin release kinetics was analyzed by Korsmeyer-Peppas equation. The result of this work showed that the optimum composition for the film were 10,2% chitosan, 61,2% carrageenan, 20,4% Tween 80 and 8,2% Span 80 which gave the optimum curcumin loading of 20,4 mg/g film. The constant of Korsmeyer-Peppas kinetics model for this film was found as 27,5 minute-0,1. The release of curcumin in the film reached maximum at 44,5% in 6 h.

Kata Kunci : kitosan, karaginan, glutaraldehid, kurkumin, pelepasan