KADAR SERUM ZINC PADA ANAK DENGAN KEJANG DEMAM DIBANDINGKAN ANAK DEMAM TANPA KEJANG

Krisye Yulanda Lawin, Elisabeth 2. Dr. dr. E Siti Herini, Sp. AK

2013 | Tesis | S2 Ked.Klinik/MS-PPDS

Latar belakang. Kejang demam merupakan kejang yang sering terjadi pada anak usia 6 bulan sampai 5 tahun. Angka kejadiannya sebesar 2-5 % populasi anak dan memiliki prognosis baik. Zinc berperan penting dalam perkembangan sistem saraf pusat. Penelitian tentang kadar serum zinc pada anak dengan kejang demam masih terbatas. Tujuan. Penelitian ini bertujuan membandingkan kadar serum zinc antara anak penderita kejang demam dengan anak demam tanpa kejang dan mengetahui korelasi antara kadar serum zinc dengan kejang demam. Metode. Penelitian kasus kontrol dilaksanakan di RSUP Dr. Sardjito dan RSUD Sleman, Yogyakarta antara Juli - Oktober 2012. Ada 38 anak kejang demam dibandingkan 38 anak dengan demam tanpa kejang usia 6 bulan hingga 5 tahun kemudian dilakukan pengukuran kadar serum zinc menggunakan metode atomic absorption spectrophotometry. Analisis data menggunakan uji t independent dan chi-square dan korelasi spearman. Hasil. Rerata kadar serum zinc pada anak dengan kejang demam 95,4 ug/dL dan pada anak demam tanpa kejang 100,9 ug/dL. Tidak terdapat korelasi antara kadar serum zinc dengan kejang demam pada anak [RO 1,49 (IK 95 % 0,428-5,191), P=0,529].

Background. Febrile seizure is the most common form of seizure in children between 6 months to 5 years of age. It occur in 2-5 % children and has good prognosis. Zinc has an important role in development of the central nervous system. The study about serum zinc level in children with febrile seizure was limited. e Objective. To compare the serum zinc level in children with and without febrile seizure and correlation between serum zinc level and febril seizure. Methods. A case-control study was conducted during July 2012 to October 2012 in Dr. Sardjito General Hospital and Sleman General Hospital, Yogyakarta. Thirty-eight children aged 6 months to 5 years with febrile seizure and 38 children with febrile without seizure were entrolled. Serum zinc level was measured using atomic absorption spectrophotometry. Data was analized with independent t test, chi-suare n spearman. Results. The mean serum zinc level in children with febrile seizure and children with febrile without seizure were 95.4 ug/dL and 100.9 ug/dL, respectively. There was no significant difference statistically between serum zinc level and febrile seizure in children [OR 1,49 (CI 95 % 0,428 to 5,191), P= 0,529].

Kata Kunci : kejang demam, kadar serum zinc, anak