STUDI PELEPASAN KURKUMIN PADA FILM N-DODESIL KITOSAN

MARIUS AGUNG SASMITA JATI, Dr. Dwi Siswanta, M.Eng

2013 | Tesis | S2 Ilmu Kimia

Telah dilakukan studi pelepasan kurkumin pada film N-dodesil kitosan (NDKit) dengan dibandingkan pada film kitosan (Kit) dan paduan (Kit-NDKit) (1:1). Kajian ini bertujuan untuk mengetahui apakah film berbasis NDKit mampu memuat kurkumin lebih banyak dan melepasnya kembali secara lebih lambat dibanding film berbasis kitosan. NDKit disintesis dari kitosan dengan dodesil bromida dalam suasana basa KOH pada suhu 70 °C selama 24 jam. Hasil sintesis dikarakterisasi dengan FTIR, 13C NMR dan XRD. Kajian meliputi optimasi waktu pemuatan kurkumin dan kemudian pelepasan kurkumin pada pH fisologis (pH = 7) diamati pada berbagai interval waktu. Data konsentrasi kurkumin yang terlepas sebagai waktu dimodelkan untuk beberapa model farmakokinetik yaitu model orde nol, orde satu, Higuchi, Hixson-Crowell dan Korsmeyer-Peppas. Karakterisasi NDKit hasil sintesis menunjukkan bahwa derajad alkilasi kitosan yang diperoleh sebesar 7,67%. Pemuatan kurkumin pada ketiga jenis film optimum pada waktu 4 jam. Film NDKit mampu memuat kurkumin lebih banyak (680,24 mg/g) dibanding film Kit (383,92 mg/g). Kajian pelepasan kurkumin pada film NDKit menunjukkan laju pelepasan yang lebih lambat (-9,93 mol/detik) dibanding film Kit (-9,49 mol/detik). Hasil analisis pemodelan farmakokinetik pada kondisi fisiologis menunjukkan bahwa NDKit merupakan kandidat bahan hantar yang baik untuk transpor obat kurkumin.

The release of curcumin from N-dodecyl chitosan films (NDKit) had been studied in comparison to the release from the films of chitosan (Kit) and Kit-NDKit blend (1:1). The aim of this study was to determine whether the film based NDKit has better capability on loading of curcumin and release the loaded-curcumin more slowly than chitosan-based films. NDKit was synthesized from chitosan with dodecyl bromide under alkaline KOH at 70 ° C for 24 hours. Synthesis results characterized by FTIR, 13C NMR and XRD. The study includes the optimization of loading time and then release curcumin curcumin in physiological pH (pH = 7) was observed at various time intervals. Concentration of released curcumin was then modeled as a function of time for several pharmacokinetic models i.e. models of zero order, first order, Higuchi, Hixson-Crowell and Korsmeyer-Peppas. Characterization NDKit showed that the degree of alkylation of chitosan obtained was 7.67%. Loading of curcumin on the three types of films was optimum at 4 hours. NDKit film has better capability for loading of curcumin (680.24 mg/g) than the Kit film (383.92 mg/g). The release of curcumin on the NDKit film was in slower rate (-9.93 mol/second) than the release from Kit film (-9.49 mol/second). Pharmacokinetic modeling results indicated that at the physiological condition of NDKit is a good candidate for a curcumin drug transport material

Kata Kunci : N-dodesil kitosan, pelepasan, pemuatan, kurkumin