PERBEDAAN RERATA KADAR ENDOTELIIV-I PADA PDREMPUAN DENGAI\ DIABETES MELITUS TIPE 2 OBES DAN NON OBES

dr. Yanti, dr. R. Bowo Pramono, SpPD-KEMD

2012 | Tesis | S2 Ked.Klinik/MS-PPDS

Latar Belakang. DM tipe II merupakan tipe DM yang tersering. Sekitar g5% adalah penderita DM tipe II dan 90Yo dari mereka dengan obesitas atau overweight. Beberapa penelitian sebelumnya menunjukkan adanya peningkatan kadar endotelin-l (ET-l) pada pasien DM tipe 2 yang obes dibandingkan dengan yang non obes. Secara epidemiologis, obesitas sentral berhubungan dengan DM tipe 2 melalui resistensi insulin. Resistensi insulin yaitu suatu keadaan hiperinsulinemia disertai penurunan kemampuan aksi insulin di perifer terutama di otot dan hati. Pada keadaan resistensinsulin terdapat peningkatan kadar ET-l. Tujuan.Mengetahui perbedaan kadar endotelin- I pada perempuan dengan diabetes mellitus tipe 2 obes dan non obes. Penelitian ini dilakukan dengan menggunakan rancangan penelitian potong lintang (cross-sectional sndy). Penelitian dilakukan di poliklinik Endokrin dan Metabolik RSUP dr. Sardjito Yogyakarta mulai bulan April 2010 sampajiu mlah sampelt erpenuhi. Metode. Karakteristik subyek penelitian disajikan dalam bentuk rerata dan simpang baku. Perbedaanr erata kadar endothelin-l antarak elompok DM tipe II obesd an non obes dianalisis dengan uji T independen, bila distribusi normal dan dengan Adann Whitney U test apabila distribusi tidak normal. Analisis statistik menggunakan program SPSS 17 dengan nilai P dianggap bermakna jika nilai p < 0.05 dengan interval kepercayana 9 5oh. Ilasil. Hasil penelitian akan disajikan dalam dummy table

Background. Type 2 diabetes is the most common type of diabetes. About 85% are people with type 2 diabetes and 90% of those with obesity or overweight. Several previous studies showed elevated levels of endothelin-1 (ET-1) in patients with type 2 diabetes are obese compared to non-obese. Epidemiologically, central obesity associated with type 2 diabetes through insulin resistance. Insulin resistance is a state of hyperinsulinemia with decreased ability of peripheral insulin action in muscle and liver especially. In a state of insulin resistance are increased levels of ET-1. Aim. To evaluate the difference plasma levels of endothelin-1 in women with type 2 diabetes mellitus obese and non-obese. Methods. Cross-sectional design was conducted on women with type 2 diabetes from clinic of the Endocrine and Metabolic RSUP. Sardjito Yogyakarta . ELISA sandwich,s method was used to measure plasma levels of endothelin-. 1. Characteristics of the study subjects are presented in the form of mean and standard deviations. The difference in the mean levels of endothelin-1 between the DM type II obese and non obese analyzed by independent T test, when normal distribution and the Mann Whitney U test if the distribution is not normal. Statistical analysis using SPSS 17 with the value of P is considered significant if the p-value <0.05 with 95% confidence intervals. Results. Result will be presented as dummy table.

Kata Kunci : endotelin-l, diabetes mellitus, obesitas