SURVIVAL RATE DAN FAKTOR PROGNOSIS PENDERITA KARSINOMA ENDOMETRIUM DI RS. DR. SARDJITO

Deyna Primavita Pahlevi, dr.Shofwal Widad, SpOG(K)

2012 | Tesis | S2 Ilmu Kebidanan dan Penyakit Kandungan

Latar belakang: Karsinoma endometrium merupakan kanker urutan ke empat pada wanita. Kelangsungan hidup penderita karsinoma endometrium dipengaruhi beberapa faktor. Di Indonesia belum didapatkan angka nasional tentang median survival penderita karsinoma endometrium dan faktor prognosis yang berpengaruh terhadap kelangsungan hidup. Tujuan penelitian: Mengetahui kelangsungan hidup penderita karsinoma endometrium yang dirawat di RS. Dr. Sardjito dan faktor prognosis yang berpengaruh terhadap kelangsungan hidup penderita karsinoma endometrium. Metode penelitian: Penelitian merupakan historical/retrospektive Cohort Study menggunakan catatan medis dan kuesioner yang dikirimkan ke alamat penderita. Subyek penelitian adalah penderita karsinoma endometrium yang dirawat di RS. Dr. Sardjito sejak 1 Januari 2006 sampai 31 Desember 2011. Kelangsungan hidup penderita karsinoma endometrium dan perbedaan median survival masingmasing faktor prognostik dianalisis dengan uji Log Rank dan disajikan berupa kurva Kaplan-meier. Faktor prognosis yang berpengaruh pada kelangsungan hidup dianalisis dengan Cox proporsional Hazard Model. Hasil: Subyek penelitian 68 pasien karsinoma endometrium, 46 pasien (69,1%) masih hidup sampai akhir penelitian. Median survival penderita karsinoma endometrium yang dirawat di RS. Dr. Sardjito adalah 32 bulan. Stadium surgikal, grade dan BMI secara statistik berbeda bermakna terhadap median survival (p=0,01, p=0,01, dan p=0,08). Faktor prognosis yang berpengaruh terhadap kelangsungan hidup adalah stadium stadium surgikal p=0,03 (HR=1,155; 95%CI 0,557-2,393), grade p=0,02 (HR=494; 95% CI.1,332–7,295) dan dan BMI p=0,02 (HR=2,703 ;95%CI.1,181-6,186). Kesimpulan: Median survival penderita karsinoma endometrium yang dirawat di RS. Dr. Sardjito adalah 32 bulan. Faktor prognosis yang berpengaruh terhadap kelangsungan hidup adalah stadium surgikal, grade dan BMI.

Background: Endometrial carcinoma is the most common malignant of female pelvis today, fourth overall cancer in women. Patient survival is influenced by number of factors. Indonesia have not gained the national rate of median survival of patients with endometrial carcinoma and prognostic factors affecting survival Objective: To evaluate survival rate of endometrial carcinoma who were treated in Dr. Sardjito hospital and to analyze survival rate prognostic factors. Methods: It was historycal/retrospective Cohort study using medical records and questioner sent to responden. Subjects were endometrial carcinoma patient who admited to Dr. Sardjito hospital since January 1st, 2006 to December 31th, 2011. Median survival and prognostic factors for endometrial carcinoma were analyzed by log rank test and presented as Kaplan-meier curves. The prognostic factors meassured by Cox proportional hazard model. Results: There were 68 subjects, 48 subjects (69. 1%) were alive until end of the study. The endometrial cancer median survival at Dr. Sardjito hospital was 38 months. There were significant difference between surgical stage (p=0.01), grade =0.01), and BMI (p=0.08) with median survival. The survival rate prognostic factors were surgical stage p= 0.029 (HR=1.155; 95%CI, 0.557-2.393), grade p=0.02 (HR=494; 95% CI, 1.332–7.295) and BMI p=0.02 (HR=2.703; 95%CI, 1.181-6.186). Conclusion:The endometrial cancer median survival at Dr. Sardjito hospital was 38 months. Surgical stage, grade and BMI were statistically significant correlation with median survival and as prognostic factors.

Kata Kunci : Kelangsungan hidup, karsinoma endometrium, stadium surgikal, BMI, faktor prognosis, Grade.