KORELASI ANTARA KADAR C-REACTIVE PROTEIN DENGAN KADAR BESI SERUM PADA ANAK DENGAN PNEUMONIA BERAT
dr. I Gede Oka Novi Purnawan, dr. Ida Bagus Subanada, Sp.A.
2011 | Tesis | S2 Ked.Klinik/MS-PPDSPneumonia adalah salah satu penyakit infeksi yang sering terjadi pada anak di bawah lima tahun. Pada saat infeksi akan dilepaskan sitokin-sitokin pro-inflamasi. Diduga sitokin-sitokin pro-inflamasi ini menyebabkan terjadinya perubahan homeostasis besi dalam tubuh. Penelitian ini bertujuan untuk mengetahui korelasi antara kadar CRP dengan kadar besi serum pada anak penderita pneumonia berat. Penelitian ini merupakan penelitian potong lintang analitik terhadap anak usia 6 bulan-5 tahun yang menderita pneumonia berat di Rumah Sakit Sanglah Denpasar sejak bulan April 2010- September 2010. Pemeriksaan laboratorium meliputi pemeriksaan kadar CRP dan kadar besi serum. Korelasi antara kadar CRP dan kadar besi serum dihitung dengan menggunakan program komputer. Dari 69 anak yang menderita pneumonia berat, 23 anak yang memenuhi kriteria inklusi dan eksklusi. Pada anak dengan pneumonia berat, rerata kadar CRP 9,22 mg/L dan kadar besi serum 25,55 ug/dL. Koefisien korelasi antara kadar CRP dan besi serum adalah -0,580 (p=0,004). Koefisien determinasi sebesar 31,6%, yang artinya sebesar 31,6% penurunan kadar besi dipengaruhi oleh peningkatan kadar CRP. Pada anak dengan pneumonia berat, kadar CRP berkorelasi negatif dengan kadar besi serum.
Pneumonia is one of the infectious disease which often occurs in children under five years old. At the time of infection, pro-inflammatory cytokines would be released. It is tought that these pro-inflammatory cytokines causes changes in iron homeostasis in the body. The objective of this study is to know the correlation between CRP levels and serum iron levels in children with severe pneumonia. An analytic cross sectional study was done on children aged 6 months-5 years old with severe pneumonia at Sanglah Hospital Denpasar from April 2010-September 2010. The laboratoric examination includes testing the CRP levels and serum iron levels. The correlation between CRP levels and serum iron levels are calculated using a computer software. From 69 children with severe pneumonia, 23 children fulfilled the inclusion and exclusion criteria. In children with severe pneumonia, the average CRP level was 9,22 mg/L and serum iron level was 25,55 ug/dL. The coefficient correlation between CRP level and serum iron level was -0,580 with p = 0,004. The determination coefficient value is 31,6 %, which means the 31,6% decrease in serum iron is influenced by the increase in CRP. In children with severe pneumonia, the CRP levels correlates negatively with the serum iron levels.
Kata Kunci : CRP, besi serum, pneumonia