Kadar resistensi pada subyek dengan dan tanpa sindrom metabolik

BOESTAMAN, Irene Vera, Prof. dr. Ahmad Husain Asdie, Sp.PD-KEMD

2010 | Tesis | S2 Ilmu Kedokteran Klinik

Sindrom metabolik merupakan sekelompok kelainan metabolik baik lipid maupun non lipid yang merupakan faktor risiko penyakit jantung koroner, yang terdiri atas obesitas sentral, dislipidemia aterogenik, hipertensi, dan glukosa plasma yang abnormal. Resistin manusia merupakan protein 12,5 kDa yang mengandung 108 asam amino. Resistin diduga mempunyai peran dalam resistensi insulin dan berkaitan dengan obesitas. Penelitian ini dilakukan untuk mengetahui perbedaan kadar Resistin pada subyek dengan sindrom metabolik dan subyek tanpa sindrom metabolik. Penelitian dilakukan menggunakan rancangan penelitian studi potong lintang pada pasien di poliklinik General Check Up dan Poliklinik Endokrin RS. Sardjito. Subyek sindrom metabolik ditentukan dengan kriteria sindrom metabolik dari International Diabetes Federation (IDF) tahun 2005 ditegakkan bila terdapat obesitas sentral (Lingkar pinggang sesuai ras) ditambah 2 kriteria atau lebih: trigliserida ≥150 mg/dL atau mendapat terapi lipid, kadar HDL-kolesterol <40 mg/dL untuk laki-laki dan <50 mg/dL untuk wanita atau mendapat terapi lipid, tekanan darah sistolik ≥130 atau diastolik ≥85 mmHg atau mendapat terapi anti hipertensi, kadar gula darah puasa ≥110 mg/Dl atau telah didiagnosa diabetes tipe 2.Pemeriksaan kadar Resistin menggunakan metode ELISA. Dari hasil penelitian didapatkan 70 subyek penelitian yang terdiri dari 40 subyek dengan sindrom metabolik dan 30 subyek tanpa sindrom metabolik.. Rerata kadar resistin pada subyek dengan sindrom metabolik yaitu 24,03±10,78 mEq/l dan rerata kadar resistin pada subyek tanpa sindrom metabolik yaitu 26,60±14,53 mEq/l. Rerata kadar resistin pada subyek dengan sindrom metabolik lebih rendah tetapi tidak bermakna dibanding pada subyek tanpa sindrom metabolik dengan nilai p=0,251. Kesimpulan penelitian ini tidak didapatkan perbedaan kadar resistin pada subyek dengan sindrom metabolik dan pada subyek tanpa sindrom metabolik.

The metabolic syndrome is metabolic disorder on lipid or non lipid that related with risk factor for cardiovascular diseases, thas is characterised by central obesity, etherogenic dyslipidemia, hypertension, and abnormal of glucose level. Resistin is a 12,5 kDa protein with 108 amino acids. Resistin is suggested as playing a role in insulin resistance and associated with obesity. The objective of this study was to know the differences mean of Resistin level in subjects with metabolic syndrome and subjects without metabolic syndrome. The design was cross-sectional study. The subjects were recruited from general check-up and endocrinology clinic, Sardjito General Hospital Yogyakarta. The diagnosis of metabolic syndrome was based on clinical criteria from IDF, diagnosis of metabolic syndrome is made when abdominal obesity with waist circumference and any two of following component are present: triglycerides ≥150 mg/dL or spesific treatment for lipid abnormality, HDL-cholesterol in men <40 mg/dL and in women <50 mg/dl or spesific treatment for lipid abnormality , blood pressure ≥130/≥85 mmHg or treatment of previously diagnosed hypertension, fasting glucose ≥110 mg/dL or previously diagnose type 2 diabetes , ELISA was used to measure plasma Resistin level. There were 70 subjects eligible in this study. The number of subjects with metabolic syndrome was 40 subjects and those without metabolic syndrome were 30 subjects. Mean of Resistin level in subjects with metabolic syndrome was 24,03±10,78 mEq/l, and mean of Resistin level in subjects without metabolic syndrome was 26,60±14,53mEq/l. Mean of Resistin level in subjects with metabolic syndrome was lower but not significant statistically compared with subjects without metabolic syndrome (p=0,251). The conclusion of this study was Resistin levels not significantly different between subjects with metabolic syndrome and subject without metabolic syndrome.

Kata Kunci : Resistin, Sindrom metabolik, Obesitas sentral