kadar leptin pada populasi non diabetes dengan dan tanpa non alcoholic fatty liver disease (NAFLD)

SOFIA, Noor Asyiqah, Prof. dr. Siti Nurdjanah, Sp.PD-KGEH, M.Kes

2010 | Tesis | S2 MSPPDS-Ilmu Penyakit Dalam

Non alcoholic fatty liver disease (NAFLD) merupakan kondisi yang cukup sering berhubungan dengan obesitas dan resistensi insulin. Leptin merupakan salah satu adipokin yang berfungsi untuk mengurangi nafsu makan dan mengontrol penggunaan energi. Peran leptin pada patogenesis NAFLD sampai saat ini masih belum jelas. Selama ini belum pernah dilakukan penelitian mengenai peranan leptin pada NAFL pada populasi non diabetes. Penelitian ini dilakukan untuk mengetahui adanya perbedaan kadar leptin serum pada subyek NAFL dan tanpa NAFL pada populasi non diabetes. Penelitian ini merupakan studi kasus control tanpa matching pada pasien general check up di RSUP Dr. Sardjito. Kriteria inklusi adalah subyek umur 30 - 60 tahun, tidak mempunyai riwayat minum alkohol > 20 gr/hari dan tidak menderita diabetes mellitus. Kriteria eksklusi meliputi hepatitis virus (hepatitis virus B dan C), penurunan berat badan yang cepat, terapi steroid, dan hamil. Diagnosis NAFL dilakukan berdasarkan gambaran bright liver pada USG. Didapatkan 48 subyek penelitian, terdiri dari 23 orang dengan NAFL dan 25 orang tanpa NAFL. Rerata kadar leptin lebih tinggi pada kelompok NAFL dibandingkan kelompok tanpa NAFL (20,29 + 15,73 ng/ml dan 12,27 + 10,1 ng/ml; p=0,040). Kesimpulan pada penelitian ini kadar leptin pada populasi non diabetes dengan NAFL adalah lebih tinggi bermakna dibanding populasi non diabetes tanpa NAFL.

Non alcoholic fatty liver disease (NAFLD) is a prevalent condition associated with obesity and insulin resistance. Leptin is an adipokine which plays role in decreasing food intake and controlling energy utilization. The role of leptin pathogenesis of NAFLD remains unclear. Former studies associated with the role of leptin in NAFLD were never conducted in diabetic patients. Therefore we aimed to analyze the difference of leptin level in non diabetic population between subjects with and without non alcoholic fatty liver . This was a non matching case control study in general check up polyclinic Dr.Sardjito Hospital Yogyakarta. The inclusion criteria were aged 30-60 years old, no history of alcohol consumption > 20 gr/day, no diabetes mellitus. The exclusion criteria were viral hepatitis (B and C), rapid weight loss, steroid therapy, and pregnancy. Diagnosis of NAFL was based on bright liver imaging from ultrasonography. There were 48 subjects consist of 23 subjects with NAFL and 25 subjects without NAFL. Mean of leptin level in NAFL group was higher than non NAFL group and this difference was statistically significant (20,29 + 15,73 ng/ml and 12,27 + 10,1 ng/ml; p=0,040). The conclusion of this study was leptin level significantly higher in non diabetic population with NAFL compared with non NAFL.

Kata Kunci : Leptin,Non alcoholic fatty liver,non diabetic