Hiperagregasi trombosit sebagai faktor risiko stroke infark

ANGGRAINI, Rinaras, dr. H. Mohammad Was'an, Sp.S(K)

2008 | Tesis | S2 Ilmu Penyakit Syaraf

Tujuan: Penelitian ini bertujuan untuk mengetahui prevalensi stroke infark yang mengalami hiperagregasi trombosit, mengetahui hubungan hiperagregasi trombosit dengan kejadian stroke infark dan mengetahui hubungan hiperagregasi trombosit terhadap faktor risiko stroke lainnya seperti hipertensi, hiperkolesterol, Diabetes Melitus, penyakit jantung dan merokok Metode Penelitian ini menggunakan desain cross-sectional. Subyek penelitian 70 orang secara consecutive sampling. Memenuhi kriteria inklusi yaitu: stroke akut usia > 18, merupakan stroke yang pertama kali dengan onset tidak lebih dari 3x24 jam setelah terjadinya serangan stroke. Kriteria eksklusi penelitian ini adalah penggunaan obat-obat anti agregasi trombosit. Status agregasi diyatakan dengan hiperagregasi positif dan hiperagregasi negatif. Outcome yang dinilai adalah stroke infark Hasil: Prevalensi stroke infark dengan hiperagregasi trombosit adalah 62%. Hiperagregasi trombosit terbukti secara signifikan merupakan faktor risiko stroke infark (p=0.001). Hubungan hiperagregasi sebagai faktor risiko stroke iskemik ini independen terhadap faktor risiko stroke lainnya seperti hipertensi, hiperkolesterol, Diabetes Melitus, penyakit jantung dan merokok. Status agregasi trombosit berhubungan dengan stroke infark merupakan hubungan yang menggambarkan doseefect . Dimana semakin tinggi status agregasi trombosit semakin besar risiko stroke infark.

Purpose: This research objective is to study the frequency of infarct stroke undergo thrombosis hyper-aggregation, correlation between thrombosis hyper-aggregation with infarct stroke, and correlation between thrombosis hyper-aggregation with others stroke risks such as hypertension, hyper-cholesterol, Diabetes mellitus, hearts disease, and smoking. This research is using cross-sectional design. Total subjects are 70 persons with consecutive sampling. Inclusion criteria are: acute stroke age ≥ 18, first stroke with onset not more than3x24 hours after stroke attack. Inclusion criteria of this research are the usage of anti thrombosis hyper-aggregation medicine. Aggregation status is defined as positive hyper-aggregation and negative hyperaggregation. The outcome is infarct stroke. Result: Frequency of infarct stroke with thrombosis hyper-aggregation is 62%. Thrombosis hyper-aggregation is proven significantly as infarct stroke risk factor (p=0.001). Correlation between hyper-aggregation as infarct stroke risk factor is independence to other factors such as hypertension, hyper-cholesterol, Diabetes mellitus, hearts disease, and smoking. Correlation of thrombosis aggregation status with other infarct stroke factors is described as dose-effect correlation in which the higher status of thrombosis aggregation the higher risks of infarct stroke.

Kata Kunci : Hiperagregasi trombosit,Stroke Infark, hyper-aggregation thrombosis, infarct stroke, risk factor