Korelasi antara status nutrisi dengan fungsi Fagositosis Netrofil pada penderita sirosis hati

INDRARTI, Fahmi, Prof.dr. Hj. Siti Nurjanah, M.Kes.,SpPD-KGEH

2007 | Tesis | PPDS I Ilmu Penyakit Dalam

Latar belakang: Status nutrisi pada penderita sirosis hati seringkali dikategorikan dalam keadaan malnutrisi bahkan banyak yang jatuh dalam kondisi status gizi buruk. Malnutrisi merupakan kondisi yang sering mengakibatkan gangguan daya tahan tubuh, dimana respons humoral dan seluler terhadap infeksi melambat, respons terhadap terapi menurun. Malnutrisi kalori protein juga berefek terhadap proses fagositosis, dimana terjadi penurunan kadar dan aktifitas komponen komplemen. Tujuan: untuk mengetahui adakah korelasi antara status nutrisi dan fungsi fagositosis sel netrofil pada penderita sirosis hati Subyek dan metoda: penelitian ini dilakukan dengan cara studi potong lintang pada bulan Agustus 2004 – Desember 2005. Subyek penelitian adalah penderita sirosis hati yang datang di Poliklinik Gastrohepatologi dan yang menjalani rawat inap di bangsal Penyakit Dalam RSUP Dr Sardjito. Sampel yang memenuhi kriteria diperiksa status nutrisi dan fungsi fagositosis netrofil. Korelasi antara status nutrisi dan fungsi fagositosis dianalisis dengan korelasi spearman. Hasil: Terdapat 44 subyek yang memenuhi kriteria. Rerata LOLA adalah 22,24±3,8 cm. Rerata nilai NBT adalah 4,4±3,2%. Hasil analisis menunjukkan korelasi antara status nutrisi dan nilai NBT adalah r=-0.101 p= 0.513. Simpulan: Tidak terdapat korelasi antara status nutrisi dan fungsi fagositosis pasien sirosis hati.

Introduction Nutritional status in liver cirrhotic patients commonly was categorized into malnutrition or even worst in poor nutritional status. Malnutrition is a condition that cause endurance body disorders, where humoral and cellular responses to infection decrease, and also to the therapy. Calorie protein malnutrition also has effects to phagocytic process, where there was decreasing of levels and activities of complement components. Aim To know whether correlation between nutritional status and neutrophil phagocytes function in cirrhotic hepatic patients. Subjects and methods: This is a cross-sectional study, performed in August 2004 to December 2005. Subjects were liver cirrhotic who visited to Gastrohepatology Clinic and Internal Medicine Inpatient wards. Subjects who fulfilled eligibility criteria were examined for nutritional status and neutrophil phagocytes function. Correlation between nutritional status and phagocytic function were analyzed by Spearman correlation test. Results: There were 44 subjects who fulfilled criteria. Mean mid-arm muscle circumference was 22,24±3,8 cm. Mean nitroblue tetrazolium was 4.4±3.2%. Results showed correlation between nutritional status and netrophil phagocytic function was r=-0.101 p= 0.513. Conclusion There was no correlation between nutritional status and netrophil phagocytes function in liver cirrhotic patients

Kata Kunci : Sirosis Hati,Status Nutrisi,Fungsi fagositosis Netrofil,Nutritional status – neutrophil phagocytic function - liver cirrhotic