Hubungan antara kadar matriks Metalloproteinase-3 cairan sendi dengan gradasi klinis pada Osteoartritis Lutut di Poliklinik Rematologi RSUP Dr. Sardjito

HASIBUAN, Petrus Junianto, dr. Nyoman Kertia, SpPD-KR

2007 | Tesis | PPDS I Ilmu Penyakit Dalam

Latar Belakang : Osteoartritis (OA) merupakan penyebab disabilitas terbesar kedua di dunia. Nyeri dan disabilitas merupakan gradasi klinis pada OA. Matrix Metalloprotease-3 (MMP-3) adalah suatu enzim yang memegang peranan penting dalam pemecahan matrik sendi yang tersusun dari kartilago. Diperkirakan kadar enzim ini berhubungan dengan gradasi klinis pada OA. Tujuan Penelitian : Untuk mengetahui korelasi antara kadar matriks metalloproteinase-3 cairan sendi dengan gradasi klinis OA lutut Metode dan Cara Penelitian : Penelitian ini dilakukan secara potong lintang pada penderita Osteoartritis lutut yang kontrol di Poliklinik Reumatologi RSUP Dr. Sardjito pada bulan September-Desember 2006. Kadar MMP-3 cairan sendi diperiksa dengan instan ELISA. Hubungan antara MMP-3 cairan sendi dengan VAS dan Indeks Lequesne dianalisis Fisher’s Exact Test dan regresi logistik Hasil : Didapatkan 21 subyek penelitian dengan laki-laki 6 dan perempuan 15. Regresi logistik mulipel antara MMP-3 dan VAS adalah p = 0,157. Fisher’s Exact Test antara MMP-3 dan indeks Lequesne adalah p = 0,031. Simpulan : Kadar matriks metalloproteinase-3 (MMP-3) cairan sendi memiliki hubungan bermakna dengan gradasi klinis OA yang diukur dengan indeks Lequesne.

Background : Osteoartritis (OA) was the second cause of disability around the world. Pain and disability were the component of clinical gradation in OA. Matrix Metalloprotease-3 (MMP-3) was an enzym which play an important role in degradation of cartilago part of joint. It was assumed that level of MMP-3 has a correlation with clinical gradation of OA. Objective : The purpose of the study was to assess the correlation between synovial matrix metalloproteinase level with clinical gradation of knee OA. Subjects and Methods : This is a cross-sectional study in patients with osteoarthritis of the knee recruited from Rheumatology Department, RSUP Dr. Sardjito, Yogyakarta on September - December 2006. Association between synovial matrix metalloproteinase level with Visual Analogue Scale and Lequesne was tested with Fisher’s Exact Test and logistic regression. Results : There were 21 subjects, 6 males and 15 females. Multiple Logistic Regression between MMP-3 and VAS was p = 0,157. Fisher’s Exact Test between MMP-3 and indeks Lequesne was p = 0,031. Conclusion : There was an association between synovial matrix metalloproteinase-3 with clinical gradation of knee OA expressed by Lequesne index.

Kata Kunci : Osteoartritis Lutut,Kadar MMP 3 dan Gradasi Klinis,Matrix metalloproteinase – Visual analogue scale – Lequesne index