Perbandingan efikasi analgetik parecoxib 40 mg (IV) dan morfin 10 mg (IV) pasca operasi elektif ginekologi mayor dengan anestesi umum

HERMAWAN, Fandi, dr. Yusmein Uyun, Sp.An.K

2006 | Tesis | S2 Ilmu Kedokteran Klinik

Tujuan Penelitian adalah mengevaluasi daya guna Parecoxib 40 mg (IV) sebagai analgetik untuk penanganan nyeri pasca operasi elektif ginekologi mayor dengan anestesi umum dibanding Morfin 10 mg (IV). Rancangan penelitian ini adalah uji klinik acak terkendali dengan pembutaan berganda. Populasi penelitian adalah pasien yang menjalani operasi elektif ginekologi mayor dengan anestesi umum di rumah sakit dr.Sardjito Yogyakarta, dr. Suradji Tirtonegoro Klaten, Prof.dr. Margono Soekardjo Purwokerto dan rumah sakit Banyumas. Subyek penelitian, 108 pasien wanita, usia 18-60 tahun, tidak menyusui, status fisik ASA I-II, berat badan 50-70 kg. Subyek dirandomisasi secara blok dibagi menjadi 2 kelompok, kelompok M (N=54) mendapat morfin 10 mg (IV) dan kelompok P (N=54) mendapat parecoxib 40 mg (IV), 30 menit sebelum operasi selesai (jahit peritoneum). Dilakukan pengamatan skor nyeri di ruang pulih sadar selama 2 jam dilanjutkan dibangsal selama 10 jam. Pengukuran Utama BPS, VPS, VAS. Analisis data menggunakan mann whitney, chi square, independent sample ttest, regresi logistik.

The objective of this research was to evaluate efficacy of parecoxib 40 mg (IV) as an analgesic to gynaecologic major operation with general anesthesia compare with morphine 10 mg (IV). Method of these research was randomized double blind controlled trial. Study population were Women undergoing elective gynaecologic major operation with general anesthesia at dr.Sardjito hospital Yogyakarta, dr. Suradji Tirtonegoro hospital Klaten, Banyumas hospital, Prof.dr. Margono Soekardjo hospital Purwokerto. Subjects were 108 women, age 18-60 years, weight 50-70 kg, not lactating, ASA I – II. Subjects were divided into two groups using block randomization, group M (N=54) received morphine 10 mg (IV) and Group P ( N=54 ) received parecoxib 40 mg (IV) at 30 minutes before the end of surgery (peritoneum closure). Observation pain scale for 2 hours in the recovery room and 10 hours at ward. Main measurement were BPS, VPS, VAS. Data analyze with mann whitney, chi square, independent sample t-test and regressi logistics.

Kata Kunci : Anestesi Umum,Analgesia,Parecoxib,Nyeri Pasca Operasi, Postoperative Pain, Analgesic, Parecoxib