Perbandingan daya guna Priming Dose Etomidate 0,06 mg/kgbb dengan 0,075 mg/kgbb dalam mencegah mioklonus pasca induksi etomidate

LIEMPY S., Tjangeta, Dr. IGN Rai Artika, SpAn.K

2006 | Tesis | PPDS I Anestesiologi dan Reanimasi

Tujuan : Membandingkan daya guna Priming Dose Etomidate 0,06 mg/kgbb dengan 0,075 mg/kgbb bolus intravena dalam mencegah kejadian mioklonus pasca induksi etomidate Desain : Randomized-control trial dengan pembutaan ganda. Ruang lingkup : Pasien-pasien yang akan menjalani operasi elektif dengan anestesi umum di Instalasi Bedah Sentral RS Dr. Sardjito Yogyakarta. Subyek : 72 pasien laki-laki dan wanita, umur 18-60 tahun, status fisik ASA I-II. Intervensi : Subyek dibagi 2 kelompok, tiap-tiap kelompok sebanyak 36 orang. Kelompok A mendapat Priming Dose Etomidate 0,075 mg/kgbb iv, kelompok B mendapat Priming Dose Etomidate 0,06 mg/kgbb iv diberikan satu menit sebelum induksi etomidate 0,3 mg/kgbb. Di ruang persiapan semua pasien diberi premedikasi dengan midazolam 0,05 mg/kgbb iv 15 menit sebelum induksi. Pengukuran : Semua pasien dilakukan pengamatan terhadap kejadian mioklonus pasca induksi etomidate. Tekanan darah non invasif, laju nadi dan saturasi oksigen dicatat tiap menit selama periode penelitian. Hasil : Kejadian mioklonus pasca induksi etomidate pada group A sebanyak 17 pasien (48%), sedangkan pada group B sebanyak 13 pasien (36%). Secara statistik tidak ada perbedaan bermakna antara kedua kelompok (p > 0,05). Kesimpulan : Pemberian priming dose etomidate 0,06 mg/kgbb dalam mencegah kejadian mioklonus pasca induksi etomidate tidak berbeda dibandingkan dengan 0,075 mg/kgbb.

Obyektif : to compare the efficacy between priming dose etomidate 0,075 mg/kgbb and 0,06 mg/kgbb intravenously for preventing incidence of myoclonus after induction of etomidate. Random : Double-blind randomized control trial. Setting : Patients underwent elective operation of major surgery under general anesthesia in central operation theatre of Dr. Sardjito Hospital Yogyakarta. Subject : 72 patients male and female, age 18-60 year, physical status ASA I-II. Intervention : The subjects were divided into two groups, each group consists 36 patients. Group A received priming dose etomidate 0,075 mg/kgbb iv, group B received priming dose etomidate 0,06 mg/kgbb iv one minute before 0,3 mg/kgbb etomidate was injected. Fifteen minutes before induction, all patients were premedicated by intravenous of midazolam 0,05 mg/kgbb. Measurement : All patients were observed for myoclonus movements after etomidate induction. Non-invasive blood pressure, heart rate and oxygen saturation were recorded every minute during the study period. Results : The incidence of myoclonus after etomidate induction in group A are 17 of 36 patients (48%), in group B are 13 of 36 patients (36%). Statistically there are no significant differences between group A and group B (p > 0,05). Conclusion : Priming dose with etomidate 0,06 mg/kgbb has no difference with etomidate 0,075 mg/kgbb in preventing the incidence of myoclonus after induction of etomidate.

Kata Kunci : Anestesia,Etomidate,Priming Dose