PERBANDINGAN KADAR ß HUMAN CHORIONIC GONADOTROPHIN (hCG) ANTARA PREEKLAMSIA BERAT DENGAN KEHAMILAN NORMOTENSI

NURHASANAH, Widiyati, Prof.Dr. HM. Sulchan Sofoewan, PhD.,SpOG(K)

2006 | Tesis | PPDS I Obstetri dan Ginekologi

Latar belakang: Etiologi dan patogenesis preeklamsia belum diketahui secara pasti. Kegagalan invasi trofoblas berakibat pada tingginya kadar β hCG diduga berperan dalam patogenesis preeklamsia. Tujuan: Mengetahui perbandingan kadar β hCG serum pada pasien dengan preeklamsia berat dengan kehamilan normotensi. Rancangan penelitian: Studi potong lintang (Cross Sectional ) Cara Penelitian: Ibu hamil dengan preeklamsia berat yang memenuhi kriteria inklusi dan eksklusi yang datang dalam kurun waktu Desember 2005 sampai Mei 2006 dilakukan pemeriksaan kadar β hCG serum. Tiga puluh pasien preeklamsia berat dan 30 pasien hamil normotensi dilakukan pemeriksaan kadar β hCG serum. Hasil: Rerata kadar β hCG serum pada preeklamsia berat yaitu 39.127 ± 15.881 mIU/mL dinyatakan berbeda bermakna dibanding pada kehamilan normotensi, yaitu 17.289 ± 5.539 mIU/mL (p =0,00). Kejadian kadar β hCG tinggi pada preeklamsia berat adalah 3,43 kali dibanding pada kehamilan normotensi. Simpulan: Ada hubungan antara kenaikan kadar β hCG serum dengan terjadinya preeklamsia berat. Kadar β hCG serum pada wanita hamil dengan preeklamsia berat lebih tinggi dibanding pada kehamilan normotensi

Background: The etiology and pathogenesis of preeclampsia were still unknown. β hCG has been suggested to play an important role on pathopysiology of the disease. Objectives: Comparing of β hCG level on preeclamptic women and normal pregnancy. Study Design: Cross Sectional Study. Materials and methods: The research was performed from December 2005 until May 2006.. All subject that fulfilled the inclusion and exclusion criteria’s were underwent β hCG serum level examination. There were 30 preeclamtic women and 30 normotemsif pregnancy Result: Sixty subject consist of 30 women with preeclampsia and 30 women with normal uncomplicated pregnancy. β hCG serum level showed significant higher level in preeclamptic patient compared to subject with normal uncomplicated pregnancy (39.127 ± 15.881 mIU/mL vs 17.289 ± 5.539 mIU/mL (p =0,00 ), but failed to show significant differences based on mothers age and parity. Multivariate analysis revealed that only preeclampsia had a significant relationship due to increased level of β hCG serum. Conclusion: β hCG serum level was higher on preeclamptic patients than normotensif pregnancy. β hCG has important role on the pathogenesis of preeclampsia.

Kata Kunci : Preeklamsia Berat,Beta hCG, β human chorionic gonadotropin, severe preeclampsia