Perbedaan Kadar Natrium Plasma dan Urin pada Pasien DM Tipe 2 dengan dan Tanpa Komplikasi Nefropati Diabetik di RSUP DR. Sardjito Yogyakarta

Emy Febryana, Dra. Tasmini, M. Kes, dr. Ahmad Hanim Sadewa, Ph. D

2009 | Skripsi | S1 PENDIDIKAN DOKTER

LATAR BELAKANG: Diabetes mellitus (DM) dengan komplikasi nefropati diabetik (ND) menjadi salah satu penyebab paling banyak dari gagal ginjal kronik di dunia. Regulasi kadar natrium plasma dan urin sangat dipengaruhi oleh fungsi ginjal. Perubahan yang terjadi pada kadar natrium plasma dan urin pada ND dapat menggambarkan fungsi ginjal. TUJUAN: Mengkaji perbedaan kadar natrium plasma dan urin serta korelasi antara keduanya pada pasien DM tipe 2 dengan dan tanpa ND. METODE: Penelltlan inl merupakan studl case-control yang dilakukan di RSUP Dr. Sardjito. Lima belas pasien DM tipe 2 dengan ND dan 20 tanpa ND telah menglkuti penelitian. Sampel berupa darah vena mediana kubiti dan urin sewaktu diambil setelah pasien menyetujJul Znformed consent. Kadar natrium plasma dan urin diukur dengan metode spektrofotometri. UJi Independent Student’s t-test dan Mann-Whitney U Test dilakukan untuk mengetahul perbedaan kadar natrium plasma dan urin. Uji korelasi Pearson dan Spearman dllakukan untuk mengetahul korelasi kadar natrium plasma dengan kadar natriumurin. HASIL: Karakteristik subyek pada pasien dengan dan tanpa ND tidak berbeda. Di antara paslen ND, subyek laki-laki sebanyak 6 orang dan perempuan 9 orang. Kadar natrium plasma dan urin memiliki perbedaan yang tidak bermakna (p=0,865; p=0,172) . Kadar natrium plasma memiliki korelasi negatif yang tidak bermakna dengan kadar natrium urin pada pasien dengan ND (r=-0,057; p=0,839) dan tanpa ND (r=— 0,442; p=0,051). KESIMPULAN: Kadar natrium plasma dan urin tidak berbeda pada kedua pasien. Kadar natrium plasma memilikl korelasi yang tidak bermakna dengan kadar natrium urin.

BACKGROUND: Diabetes mellitus (DM) with diabetic nephropathy (DN) complication become one of the most cause of chronic renal failure in the world. Regulation of sodium plasma and urine level was greatly influenced by kidney function. Any changes in the level of sodium in plasma and urine in DN can figure out the funetion of the kidney. OBJECTIVE: To investigate the difference of the level of sodium in plasma and urine and correlation between them in DM type 2 patients with and without DN. METHODS: This research was a case-control study conducted at Dr. Sardjito Hospital. Fifteen patients with DN and 20 patients without DN were enrolled. Blood samples from mediana cubitl veln and on the spot urine samples were collected from patients after obtained informed consent. Sodium plasma and urine level were measured by spectrophotometry method. Independent Student’s t-test and Mann-Whitney U Test were performed to examine the difference of the level of sodlum in plasma and urine. Pearson and Spearman test were performed to examine the correlation between sodlum plasma level with sodium urine level. RESULTS: Characteristics subjJect with and without DN was not different. Among DN patients, male was 6 people and female was 9 people. Sodium plasma and urine level have a non-significant difference in patients with and without DN (p=0,865; p=0,172). Sodium plasma level has a nonsignificant negative correlation with sodium urine level in patients with DN (r=-0,057; p=0,839) and without DN (r=- 0,442; p=0,051). CONCLUSION: Sodium plasma and urine level was not different in both patlents. Sodium plasma level has a non-significant correlation with sodium urine level.

Kata Kunci : sodium, nefropatl diabetlk, dlabetesmellitus