Pengaruh Hidrasi dan Frekuensi Urinasi terhadap Laju Eliminasi Iodium-131 Pasien Kanker Tiroid Dosis 150 mCi

Djosiska Aisyah Rahma, Ir. Ester Wijayanti, M.T., IPM.; dr. Hanif Afkari, Sp.KN-TM, Sub.Sp.Onk(K)

2026 | Skripsi | TEKNIK NUKLIR

Differentiated Thyroid Cancer (DTC) dapat ditangani dengan terapi iodium-131 setelah tiroidektomi total. Hidrasi dan urinasi diperkirakan membantu pengeluaran iodium-131, tetapi hubungannya dengan laju eliminasi belum sepenuhnya diketahui. Penelitian ini bertujuan menganalisis hubungan volume air minum total dan frekuensi urinasi dengan laju eliminasi iodium-131 pada pasien yang menerima aktivitas 150 mCi.

??Penelitian observasional analitik prospektif dilakukan pada 29 pasien. Laju dosis eksternal diukur pada jarak 1 meter pada jam ke-5, 21, 24, 29, dan 45 setelah pemberian iodium-131. Laju eliminasi direpresentasikan secara tidak langsung oleh konstanta laju penurunan efektif (?eff) dari model monoeksponensial. Hubungan utama dianalisis menggunakan korelasi Pearson.

??Rerata ?eff sebesar 0,04214 jam^-1<!--[if gte msEquation 12]>jam-1<![endif]--><!--[if !msEquation]--><!--[endif]-->. Volume air minum total tidak berhubungan bermakna dengan <!--[if gte msEquation 12]>?eff<![endif]--><!--[if !msEquation]--> <!--[endif]--> ?eff (r=-0,320; p=0,090), demikian pula frekuensi urinasi (r=-0,329; p=0,081) dan total volume urin pada 18 pasien (r=-0,026; p=0,919). Volume air minum total berhubungan positif dengan frekuensi urinasi (r=0,655; p<0>). Sebanyak 26 pasien memenuhi kriteria rilis pada jam ke-45. Hidrasi dan urinasi belum menunjukkan hubungan bermakna dengan ?eff <!--[endif]-->sehingga pemantauan laju dosis secara individual tetap diperlukan.

Differentiated thyroid cancer can be treated with iodine-131 after total thyroidectomy. Hydration and urination are expected to support iodine-131 excretion, but their relationship with the elimination rate remains unclear. This study analyzed the relationships of total water intake and urination frequency with the iodine-131 elimination rate in patients receiving 150 mCi.

??A prospective analytical observational study included 29 patients. External dose rate was measured at 1 m at 5, 21, 24, 29, and 45 hours after iodine-131 administration. The elimination rate was indirectly represented by the effective decline-rate constant (?eff) obtained from a monoexponential model. The main relationships were analyzed using Pearson correlation.

??The mean ?eff was 0.04214 h^-1<!--[if gte msEquation 12]>h-1<![endif]--><!--[if !msEquation]--><!--[endif]-->. Total water intake was not significantly correlated with ?eff (r=-0,320; p=0.090), nor were urination frequency (r=-0.329; p=0,081) and total urine volume in 18 patients (r=-0.026; p=0.919). Total water intake was positively correlated with urination frequency (r=0.655; p<0>). Twenty-six patients met the release criterion at 45 hours. Hydration and urination were not significantly associated with ?eff; therefore, individual external dose-rate monitoring remains necessary.

Kata Kunci : hidrasi, iodium-131, laju dosis eksternal, laju eliminasi, urinasi