Pengaruh Pemberian Kombinasi Herbal dan Lisozim sebagai Alternatif Antibiotic Growth Promoter terhadap Performa Produksi dan Biokimia Darah Broiler COBB 500

Almalya Naura Putri Ariyanto, drh. Imron Rosyadi, M.Sc., Ph.D.

2026 | Skripsi | KEDOKTERAN HEWAN

Penggunaan antibiotic growth promoter (AGP) yang telah dilarang dalam industri perunggasan mendorong kebutuhan akan alternatif yang lebih aman dan efektif. Penelitian ini bertujuan mengevaluasi pengaruh pemberian kombinasi herbal dan lisozim terhadap performa produksi dan parameter biokimia darah ayam broiler sebagai alternatif AGP. Sebanyak 75 ekor ayam broiler galur COBB 500 dibagi merata ke dalam 3 kelompok, masing-masing 25 ekor, yaitu kelompok  normal, kelompok AGP, dan kelompok perlakuan kombinasi herbal dan lisozim. Pemeliharaan dilakukan selama 28 hari di Unit Pelaksana Penelitian Perunggasan dan Pelatihan Manajemen Kesehatan Unggas (UP4MKU), dan pengambilan sampel darah dilakukan pada hari ke-28. Pemeriksaan biokimia darah dilakukan di Laboratorium Patologi Klinik Fakultas Kedokteran Hewan Universitas Gadjah Mada. Data dianalisis secara deskriptif dan inferensial melalui uji normalitas, homogenitas, ANOVA, serta uji nonparametrik menggunakan Jeffrey's Amazing Statistics Program (JASP). Hasil menunjukkan bahwa pertambahan bobot badan (PBB) kelompok perlakuan relatif setara dengan kelompok normal dan lebih tinggi dibandingkan kelompok AGP. Nilai feed conversion ratio (FCR) pada kelompok perlakuan tidak berbeda signifkan dengan kelompok AGP (p>0,05), namun lebih tinggi dibandingkan kelompok normal (p<0>0,05). Kadar aspartate aminotransferase (AST), fosfor, total protein, dan natrium kelompok perlakuan lebih tinggi, sedangkan kadar asam empedu, kreatin kinase, asam urat, glukosa, dan globulin lebih rendah dibandingkan kedua kelompok (p<0>

The use of antibiotic growth promoters (AGPs), which have been  banned in the poultry industry, has driven the need for safer and more effective alternatives. This study aims to determine the effect of a combination of herbs and lysozyme on production performance and blood biochemical parameters of broiler chickens were divided equally into three groups of 35 each: the normal group, the AGP group, and the herbal and lysozyme combination treatment group. Maintenance was carried out for 28th days at the poultry Research and Poultry Health Management Training Unit (UP4MKU), and blood sampling was carried out at the Clinical Pathology Laboratory  of the Faculty of Veterinary Medicine, Universitas Gadjah Mada. Data were analyzed descriptively and inferentially through normality tests, homogeneity tests, ANOVA tests, and nonparametric tests using Jeffreys’s Amazing Statistics Program (JASP). The results showed that the body weight gain (BWG) of the treatment group was relatively equivalent to the normal group and higher than the AGP group. The feed conversion ratio (FCR) in the treatment group was not significantly different from the AGP group (p>0.05), but was higher than the normal group (p<0>0.05). The levels of aspartate aminotransferase (AST), phosphorus, total protein, and sodium were higher in the treatment group, while the levels of bile acids, creatine kinase, uric acid, glucose, and globulin were lower than in both groups (p<0>

Kata Kunci : biokimia darah, broiler, herbal, lisozim, performa produksi, blood biochemistry, broiler, herbs, lysozyme, production performance