HUBUNGAN IL-6 TERHADAP DURASI RAWAT ICU PADA PASIEN PASKA OPERASI BEDAH JANTUNG DENGAN MESIN PINTAS JANTUNG PARU DI RSUP DR. SARDJITO

Yusuf Kirana Raksawardana, Dr. dr. Bhirowo Yudo Pratomo, SpAn-TI, Subsp. An. KV(K); Dr. dr. Juni Kurniawaty, SpAn-TI, M.Sc, Subsp. An. KV(K)

2026 | Tesis-Spesialis | S2 Anestesiologi

Latar Belakang: Operasi bedah jantung dengan cardiopulmonary bypass (CPB) memicu respons inflamasi sistemik yang ditandai peningkatan kadar Interleukin-6 (IL-6), yang berpotensi memperpanjang durasi rawat ICU. Penelitian ini bertujuan mengeksplorasi hubungan antara kadar IL-6 dengan durasi rawat ICU pada pasien pascaoperasi bedah jantung dengan CPB di RSUP Dr. Sardjito, Yogyakarta.

Metode: Studi cohort prospektif melibatkan pasien dewasa (?17 tahun) dengan NYHA kelas III. Eksklusi mencakup penggunaan alat bantu sirkulasi praoperasi, inflamasi berat, atau bedah emergensi. Analisis menggunakan uji normalitas Shapiro-Wilk, korelasi Spearman, serta analisis bivariat dan multivariat.

Hasil: Sebanyak 47 pasien dianalisis dengan rerata usia 46,43 ± 13,47 tahun (median 48 tahun) dan mayoritas laki-laki (57,4%). Durasi CPB ?90 menit terjadi pada 48,9% pasien. Rerata kadar IL-6 post-CPB sebesar 143,06 ± 171,39 pg/mL (median 94,08 pg/mL). Rerata durasi rawat ICU 100,37 ± 72,26 jam (median 80,0 jam, rentang 31,5–387,0 jam). Uji Spearman menunjukkan hubungan negatif lemah yang signifikan antara IL-6 post-CPB dengan durasi rawat ICU (r = ?0,277; p = 0,030). Analisis multivariat mengidentifikasi hipertensi sebagai faktor yang secara signifikan memengaruhi durasi rawat ICU (B = 47,685; p = 0,049), sedangkan IL-6 tidak signifikan secara independen (B = ?0,090; p = 0,138).

Kesimpulan: Tidak terdapat hubungan positif antara kadar IL-6 post-CPB dengan durasi rawat ICU pada pasien bedah jantung dengan mesin pintas jantung-paru di RSUP Dr. Sardjito, Yogyakarta.

Background: Cardiac surgery with cardiopulmonary bypass (CPB) frequently triggers a systemic inflammatory response characterized by elevated Interleukin-6 (IL-6) levels, which may prolong ICU length of stay. This study aimed to explore the relationship between IL-6 levels and ICU length of stay in patients undergoing cardiac surgery with CPB at Dr. Sardjito General Hospital, Yogyakarta.

Methods: This prospective cohort study included adult patients (?17 years) with NYHA class III. Exclusion criteria comprised preoperative circulatory assist device use, severe inflammatory conditions, or emergency surgery. Analysis included Shapiro-Wilk normality test, Spearman correlation, bivariate, and multivariate analysis.

Results: A total of 47 patients were analyzed with a mean age of 46.43 ± 13.47 years (median 48 years), majority male (57.4%). CPB duration ?90 minutes occurred in 48.9% of patients. Mean post-CPB IL-6 was 143.06 ± 171.39 pg/mL (median 94.08 pg/mL). Mean ICU length of stay was 100.37 ± 72.26 hours (median 80.0 hours, range 31.5–387.0 hours). Spearman correlation revealed a significant weak negative relationship between post-CPB IL-6 and ICU length of stay (r = ?0.277; p = 0.030). Multivariate analysis identified hypertension as a significant predictor of ICU length of stay (B = 47.685; p = 0.049), while post-CPB IL-6 was not independently significant (B = ?0.090; p = 0.138).

Conclusion: No positive relationship was found between post-CPB IL-6 levels and ICU length of stay in cardiac surgery patients with CPB at Dr. Sardjito General Hospital, Yogyakarta.

Kata Kunci : IL-6, Durasi rawat ICU, Bedah jantung, Mesin pintas jantung-paru