The Relationship Between ROX Index and The Degree of Severity of Acute Respiratory Distress Syndrome Measured by AaDO2 After HFNC in Severe and Critical COVID-19 Patients

Muhammad Fadlirafiq Hutasuhut, 1. dr. Heni Retno Wulan, M.Kes, SpPD-KP 2. dr. Rizka Humardewayanti, SpPD, KPTI

2026 | Skripsi | PENDIDIKAN DOKTER

Acute Respiratory Distress Syndrome (ARDS) merupakan kondisi yang sering ditemukan pada pasien COVID-19. ARDS adalah kondisi yang mengancam jiwa dan dapat dievaluasi menggunakan indeks ROX. Indeks ROX merupakan suatu skor yang digunakan untuk menilai kondisi gangguan pernapasan akut pada pasien COVID-19. Untuk mengevaluasi hubungan antara indeks ROX dengan derajat keparahan Acute Respiratory Distress Syndrome (ARDS) setelah pemberian terapi High Flow Nasal Cannula (HFNC) pada pasien COVID-19 derajat berat dan kritis. Desain penelitian ini adalah studi cross-sectional retrospektif dengan populasi penelitian berupa pasien dewasa dengan COVID-19 derajat berat dan kritis di RSUP Dr. Sardjito Yogyakarta pada tahun 2021. Variabel independen dalam penelitian ini adalah indeks ROX, sedangkan variabel dependen adalah nilai AaDO?. Faktor perancu (confounders) potensial dalam penelitian ini meliputi usia lanjut, neutrofilia, dan gangguan koagulasi. Analisis statistik terdiri dari analisis univariat, bivariat, dan multivariat.

1.Background

Acute respiratory distress syndrome is common with patient who dealt with COVID-19. Acute respiratory distress syndrome is life threatening which is shown with high ROX index score. ROX index is the score to evaluate acute respiratory distress syndrome for the COVID-19 patient.

2.Objective

To evaluate the relationship ROX index for acute respiratory distress syndrome after high flow nasal cannula in severe and critical COVID-19 patient

3.Method
The research design of this study is retrospective cross-sectional study with the research population of adult with severe and critical COVID 19 patients in RSUP dr. Sardjito Yogyakarta in 2021. The independent variable in this study is ROX index and the dependent variable is AADO2. The potential cofounders are older age, neutrophilia, and coagulation dysfunction.

4.Statistical

Analysis Statistical analysis consists of univariate, bivariate, and multivariate. Univariate analysis is used for computing the distribution and frequency of each research variable. Bivariate contains Chi-square test or fisher exact test and simple regression test. Chi square test or fisher exact test is used for computing the proportion different of acute respiratory distress syndrome after high flow nasal cannula between groups. Simple logistic regression is used for computing the relationship between ROX index and AADO2. Multivariate logistic regression is used for computing the relationship between ROX index, confounders, and AADO2. 

Keywords: Severe COVID-19, critical COVID-19, AADO2, ROX index, Retrospective cross-sectional study

Kata Kunci : Severe COVID-19, critical COVID-19, AADO2, ROX index, Retrospective cross-sectional study