THROMBOCYTOPENIA AS A PREDICTOR OF MORTALITY AMONG CHILDREN WITH CONGENITAL HEART DISEASE
Syaqhina Nifa Hidayat, dr.Nadya Arafuri,M.Sc.A(K)., ; Prof.dr.Indah Kartika Murni,M.Kes,Sp.A(K).,Ph.D.,
2026 | Skripsi | PENDIDIKAN DOKTER
Background: Congenital Heart Disease (CHD) has a high mortality rate of 81 cases
per 100,000 live births, leading cause of infant mortality. Previous studies revealed that
thrombocytopenia is a significant predictor of increased mortality in CHD patients. It
exacerbates cardiovascular complications and serves as an indicator of underlying
inflammatory processes that further deteriorate patient outcomes. By identifying and
understanding the impact of thrombocytopenia on CHD, this study provides critical
insights that could lead to improved management strategies, more effective
interventions, and ultimately, a reduction in mortality rates among these vulnerable
patients. Therefore, this study aims to evaluate thrombocytopenia as a predictor of
inpatient mortality among children with CHD
Objective: To evaluate thrombocytopenia as a predictor of inpatients mortality among
children with congenital heart disease at RSUP Dr.Sardjito
Methods: A retrospective cohort study was conducted by analyzing medical records
from the Department of Pediatrics at RSUP Dr. Sardjito over a defined period.
Thrombocytopenia at the time of hospital admission served as the independent
variable, along with other prognostic factors including sex, age at diagnosis, and
comorbidities. The dependent variable was inpatient mortality status. The relationship
between thrombocytopenia, other predictors, and inpatient mortality was assessed
using multivariate logistic regression analysis.
8Result: A total of 234 samples were included in this study, all of whom were inpatients
diagnosed with congenital heart disease (CHD) and evaluated for thrombocytopenia.
The baseline characteristics of these patients, categorized by mortality outcomes (non-
survivors, n = 36; survivors, n = 198). Variables included demographic data, CHD type,
thrombocytopenia status, medication use, presence of genetic syndromes,
socioeconomic status, and complications. Among the variables assessed, age under five
years, presence of thrombocytopenia, and clinical complications were significantly
associated with higher mortality in children with CHD, underscoring their potential
value as prognostic indicators in this patient population.
Conclusion: Age, thrombocytopenia, and the presence of complications were
significant predictors of mortality in children with CHD.
Keyword : Thrombocytopenia, mortality, risk factor, congenital heart disease.
Background: Congenital Heart Disease (CHD) has a high mortality rate of 81 cases
per 100,000 live births, leading cause of infant mortality. Previous studies revealed that
thrombocytopenia is a significant predictor of increased mortality in CHD patients. It
exacerbates cardiovascular complications and serves as an indicator of underlying
inflammatory processes that further deteriorate patient outcomes. By identifying and
understanding the impact of thrombocytopenia on CHD, this study provides critical
insights that could lead to improved management strategies, more effective
interventions, and ultimately, a reduction in mortality rates among these vulnerable
patients. Therefore, this study aims to evaluate thrombocytopenia as a predictor of
inpatient mortality among children with CHD
Objective: To evaluate thrombocytopenia as a predictor of inpatients mortality among
children with congenital heart disease at RSUP Dr.Sardjito
Methods: A retrospective cohort study was conducted by analyzing medical records
from the Department of Pediatrics at RSUP Dr. Sardjito over a defined period.
Thrombocytopenia at the time of hospital admission served as the independent
variable, along with other prognostic factors including sex, age at diagnosis, and
comorbidities. The dependent variable was inpatient mortality status. The relationship
between thrombocytopenia, other predictors, and inpatient mortality was assessed
using multivariate logistic regression analysis.
8Result: A total of 234 samples were included in this study, all of whom were inpatients
diagnosed with congenital heart disease (CHD) and evaluated for thrombocytopenia.
The baseline characteristics of these patients, categorized by mortality outcomes (non-
survivors, n = 36; survivors, n = 198). Variables included demographic data, CHD type,
thrombocytopenia status, medication use, presence of genetic syndromes,
socioeconomic status, and complications. Among the variables assessed, age under five
years, presence of thrombocytopenia, and clinical complications were significantly
associated with higher mortality in children with CHD, underscoring their potential
value as prognostic indicators in this patient population.
Conclusion: Age, thrombocytopenia, and the presence of complications were
significant predictors of mortality in children with CHD.
Kata Kunci : Thrombocytopenia, mortality, risk factor, congenital heart disease.
