Hubungan Kadar Asam Urat dengan Skor Penyakit Kardiovaskular Aterosklerotik pada Pasien Obesitas Sentral tanpa Diabetes

Puspito Dewi, dr. Hemi Sinorita, SpPD, K-EMD.; dr. Hasanah Mumpuni, M.Sc, SpPD, K-KV, Sp.JP(K)

2026 | Tesis-Subspesialis | SUBSPESIALIS ILMU PENYAKIT DALAM

Latar Belakang: Asam urat sebagai faktor risiko non-tradisional diduga berperan dalam peningkatan risiko penyakit kardiovaskular aterosklerotik melalui mekanisme stres oksidatif dan disfungsi endotel. Hubungan ini menjadi lebih relevan pada individu dengan obesitas sentral.

Tujuan: Menganalisis hubungan kadar asam urat dengan risiko penyakit kardiovaskular pada pasien obesitas sentral tanpa diabetes melitus.

Metode: Penelitian ini merupakan studi analitik observasional dengan desain potong lintang. Subjek penelitian adalah pasien obesitas sentral tanpa diabetes melitus. Data yang dikumpulkan meliputi karakteristik subjek, parameter klinis dan laboratorium, serta skor risiko kardiovaskular yang dinilai menggunakan Framingham Risk Score. Analisis statistik meliputi uji korelasi, analisis ROC, serta regresi logistik multivariat.

Hasil: Terdapat hubungan positif yang kuat antara kadar asam urat dan skor risiko penyakit kardiovaskular aterosklerotik (r = 0,826; p < 0 xss=removed xss=removed>

Kesimpulan: Kadar asam urat dan lama obesitas berhubungan secara independen dengan peningkatan risiko penyakit kardiovaskular pada pasien obesitas sentral tanpa diabetes melitus.

Background: Uric acid, as a non-traditional risk factor, is suggested to contribute to an increased risk of atherosclerotic cardiovascular disease through mechanisms involving oxidative stress and endothelial dysfunction. This association is particularly relevant in individuals with central obesity.

Objective: To analyze the association between serum uric acid levels and the risk of cardiovascular disease in non-diabetic patients with central obesity.

Methods: This study was an analytical observational study with a cross-sectional design. The subjects were non-diabetic patients with central obesity. Data collected included subject characteristics, clinical and laboratory parameters, and cardiovascular risk scores assessed using the Framingham Risk Score. Statistical analyses included correlation tests, receiver operating characteristic (ROC) analysis, and multivariate logistic regression.

Results: A strong positive correlation was found between serum uric acid levels and atherosclerotic cardiovascular disease risk scores (r = 0.826; p < 0 xss=removed xss=removed>

Conclusion: Serum uric acid level and duration of obesity are independently associated with an increased risk of cardiovascular disease in non-diabetic individuals with central obesity.

Kata Kunci : asam urat, obesitas sentral, risiko kardiovaskular aterosklerotik, Framingham Risk Score.