PENGARUH PEMBERIAN IRIGASI CHLORHEXIDINE 0,2% TERHADAP KADAR C-REACTIVE PROTEIN DAN PLATELET-TO-LYMPHOCYTE RATIO PASCAODONTEKTOMI MOLAR KETIGA MANDIBULA

Refitia Inayah Putri, drg. Cahya Yustisia Hasan, Sp.B.M.Mf., Subsp. C.O.Mf; drg. Didit Istadi, Sp.B.M.Mf, Subsp. Ped.O.Mf

2026 | Tesis-Spesialis | S2 Ilmu Bedah Mulut

Latar belakang: Tindakan odontektomi molar ketiga mandibula menyebabkan trauma jaringan yang memicu respons inflamasi lokal dan sistemik, yang berperan dalam proses penyembuhan serta risiko komplikasi pascaoperasi. Respons inflamasi sistemik tersebut dapat dievaluasi melalui biomarker C-Reactive Protein (CRP) dan Platelet-to-Lymphocyte Ratio (PLR). Irigasi chlorhexidine (CHX) 0,2% sebagai antiseptik spektrum luas diharapkan mampu menurunkan beban bakteri pada area pembedahan sehingga berpotensi memodulasi respons inflamasi pascaodontektomi.

Tujuan: Mengevaluasi pengaruh irigasi CHX 0,2% terhadap perubahan kadar CRP dan PLR pada H+1 dan H+7 pascaodontektomi molar ketiga mandibula dengan anestesi lokal.
Metode: Penelitian ini merupakan randomized controlled double blind clinical trial terhadap 40 subjek dalam dua kelompok CHX (n=20) dan kontrol (n=20). Kadar CRP diperiksa dengan metode ELISA dan PLR diperoleh dari pemeriksaan darah lengkap. Analisis menggunakan General Linear Model Repeated Measure ANOVA dengan tingkat signifikansi 95%.

Hasil:Terdapat interaksi bermakna antara waktu dan perlakuan pada CRP (p=0,006) dan PLR (p=0,000). Pada H+1, kadar CRP dan PLR kelompok CHX lebih rendah dibandingkan kontrol (p<0>biomarker menurun mendekati kadar praoperasi tanpa perbedaan bermakna antar kelompok. Kesimpulan:Irigasi dengan chlorhexidine 0,2% secara efektif menekan peningkatan akut CRP dan PLR pascaoperasi, yang menunjukkan potensi perannya dalam memodulasi respons inflamasi sistemik setelah odontektomi.

Kata kunci: Chlorhexidine, C-Reactive Protein, Platelet-to-Lymphocyte Ratio

Background: Mandibular third molar odontectomy induces tissue trauma that triggers both local and systemic inflammatory responses, which influence the healing process and the risk of postoperative complications. The systemic inflammatory response can be assessed using biomarkers such as C-Reactive Protein (CRP) and the Platelet-to-Lymphocyte Ratio (PLR). Irrigation with 0.2% chlorhexidine (CHX), a broad-spectrum antiseptic, is expected to reduce the bacterial load at the surgical site and thereby potentially modulate the postoperative inflammatory response.

Objective: To evaluate the effect of 0.2% CHX irrigation on changes in CRP levels and PLR on day 1 and day 7 after mandibular third molar odontectomy under local anesthesia.
Methods: This study was a randomized controlled double-blind clinical trial involving 40 subjects divided into CHX (n=20) and control (n=20) groups. CRP levels were measured using the ELISA method, and PLR was calculated from complete blood count results. Data were analyzed using the General Linear Model Repeated Measures ANOVA with a 95% significance level.

Results: A significant interaction between time and treatment was observed for CRP (p=0.006) and PLR (p=0.000). On postoperative day 1, CRP levels and PLR were lower in the CHX group compared to the control group (p<0>

Conclusion: Irrigation with 0.2% chlorhexidine effectively attenuated the acute postoperative increase in CRP and PLR, indicating its potential role in modulating the systemic inflammatory response after odontectomy.

Keywords: Chlorhexidine, C-Reactive Protein, Platelet-to-Lymphocyte Ratio

Kata Kunci : Chlorhexidine, C-Reactive Protein, Platelet-to-Lymphocyte Ratio