Hubungan Antara CRP-Albumin-Limfosit Skor Terhadap Mortalitas Pada Pasien COVID-19 Derajat Berat Dan Kritis Di RSUP Dr. Sardjito

Lucy Alfina Damayanti, Dr. dr. Heni Retno Wulan, M.Kes.,Sp.PD-KPMK; Dr. dr. Ayu Paramaiswari Sp.PD-KR

2026 | Skripsi | PENDIDIKAN DOKTER

Latar belakang: Penyakit Corona virus (Covid-19) merupakan penyakit yang disebabkan oleh virus SARS- CoV-2. Penderita virus tersebut dapat mengalami gejala ringan maupun berat. Penyebaran Corona virus termasuk cepat melalui batuk, bersin, maupun droplet ketika penderita berbicara. Skor CRP-albumin-limfosit (CALLY) merupakan alat penilaian imunonutritif yang didasarkan pada serum protein (CRP), serum albumin, dan jumlah limfosit. 

Tujuan: Penelitian ini bertujuan untuk menganalisis hubungan antara Skor CALLY dan mortalitas pada pasien Covid-19 derajat berat dan kritis di RSUP Dr. Sardjito.

Metode: Partisipan dalam penelitian yaitu pasien Covid-19 derajat berat dan kritis pada RSUP DR. Sardjito periode 1 Maret-31 Desember 2021. Variabel terikat pada penelitian yaitu mortalitas sedangkan variabel bebasnya merupakan Skor CALLY. Desain yang digunakan yaitu studi cohort retrospective. Analisis deskriptif digunakan untuk menghitung distribusi dan frekuensi penelitian setiap variabel penelitian. Kai-square akan digunakan dalam perhitungan beda proporsi angka kemudian dilanjutkan dengan penentuan titik potong variabel bebas atau Skor CALLY menggunakan grafik ROC. Analisis keeratan hubungan antara Skor CALLY dan mortalitas diuji menggunakan regresi logistik sederhana.

Hasil: Diperoleh 282 rekam medis pasien yang diambil secara berturut-turut dan telah memenuhi kriteria. Penentuan nilai batas akan menggunakan nilai sensitivitas (Sn) sebesar 36,8 dan nilai 1-spesifisitas (Sp) sebesar 0,196. Ambang batas yang telah ditentukan pada penelitian yaitu 1.892. Nilai p sebesar 0, 027 menunjukkan hasil uji signifikan secara statistik dan nilai cutoff yang telah ditetapkan untuk mengelompokkan subjek berdasarkan tingkat skor CALLY.

Kesimpulan: Dalam penelitian ini diketahui bahwa terdapat hubungan signifikan antara CALLY skor terhadap mortalitas pada pasien Covid-19 derajat berat dan kritis di RSUP DR. Sardjito dengan relative risk sebesar 1.143. 

Background: Coronavirus disease 2019 (COVID-19) is caused by the SARS-CoV-2 virus. Infected individuals may experience mild to severe symptoms. The virus spreads rapidly through droplets produced by coughing, sneezing, or speaking. The C-reactive protein–albumin–lymphocyte (CALLY) score is an immunonutritional assessment tool based on serum C-reactive protein (CRP), serum albumin levels, and lymphocyte count.

Objective: This study aimed to analyze the association between the CALLY score and mortality among patients with severe and critical COVID-19 at RSUP Dr. Sardjito.

Methods: The participants were patients diagnosed with severe and critical COVID-19 at RSUP Dr. Sardjito during the period of March 1 to December 31, 2021. The dependent variable was mortality, while the independent variable was the CALLY score. A retrospective cohort study design was employed. Descriptive analysis was used to determine the distribution and frequency of each research variable. The chi-square test was applied to analyze differences in proportions, followed by determination of the optimal cut-off point for the CALLY score using the ROC curve. The strength of the association between the CALLY score and mortality was assessed using simple logistic regression analysis.

Results: A total of 282 medical records were collected consecutively and met the inclusion criteria. The cut-off value was determined using a sensitivity (Sn) of 36.8% and a 1–specificity (Sp) value of 0.196. The established cut-off point in this study was ? 1.892. A p-value of 0.027 indicated a statistically significant result, and the determined cut-off value was used to classify subjects based on their CALLY score levels.

Conclusion: This study demonstrated a significant association between the CALLY score and mortality among patients with severe and critical COVID-19 at RSUP Dr. Sardjito, with a relative risk of 1.143.

Kata Kunci : Pasien Covid, Skor CALLY, CRP, Mortalitas, RSUP Dr. Sardjito