Perbedaan Gambaran Klinikopatologi Invasive Lobular Carcinoma (ILC) dan Invasive Ductal Carcinoma (IDC) pada Pasien Kanker Payudara di RSUP Dr. Sardjito

Reyfandi Nawal Pratama, Prof. Dr. dr. Irianiwati, Sp. PA (K); Dr.rer.nat. dr. Dyah Laksmi Dewi, M. Sc., Sp. B; Dr. Auliya Suluk Brilliant Sumpono, Sp. PA

2025 | Skripsi | PENDIDIKAN DOKTER

Latar belakang: Kanker payudara adalah kanker yang paling sering didiagnosis pada wanita di seluruh dunia. Dua subtipe histopatologi tersering adalah Invasive Lobular Carcinoma (ILC) dan Invasive Ductal Carcinoma (IDC). Kedua tipe tumor tersebut terjadi di terminal duct lobular unit payudara. IDC menyumbang sekitar ±80% kasus dan berasal dari ductus terminalis, sedangkan ILC (±10%) berasal dari lobulus glandula mammae. Secara klinikopatologi, ILC umumnya memiliki tumor grade rendah, ukuran tumor lebih besar, jarang bermetastasis ke kelenjar getah bening, serta menunjukkan ekspresi ER+/PR+, HER2-, dan Ki67 rendah sehingga cenderung berprognosis lebih baik dibandingkan dengan IDC. Oleh karena itu, analisis perbedaan gambaran klinikopatologis antara IDC dan ILC pada kanker payudara penting dilakukan agar prognosis dan manajemen dapat ditegakkan lebih tepat. 

Tujuan: Menganalisis perbedaan gambaran klinikopatologi ILC dan IDC pada pasien kanker payudara di RSUP Dr. Sardjito.

Metode: Penelitian ini merupakan studi observasional analitik dengan desain potong lintang menggunakan data rekam medis pasien kanker payudara yang terdiagnosis pada tahun 2021–2025 di RSUP Dr. Sardjito. Variabel yang ditinjau meliputi ukuran tumor, status kelenjar getah bening, invasi limfovaskular, tumor-infiltrating lymphocyte, grade, serta ekspresi ER, PR, HER2, dan Ki-67. Analisis statistik dilakukan menggunakan SPSS versi 29.0.2.0.

Hasil: Diperoleh frekuensi ILC sebesar 4,8?n IDC 95,2%. Terdapat perbedaan bermakna antara ILC dan IDC pada grade tumor (p < 0 xss=removed xss=removed xss=removed xss=removed xss=removed xss=removed>tumor-infiltrating lymphocyte (p = 0.579), maupun Ki-67 (p = 1.000).

Background: Breast cancer is the most frequently diagnosed cancer among women worldwide. The two most common histopathological subtypes are Invasive Lobular Carcinoma (ILC) and Invasive Ductal Carcinoma (IDC), both arising from the terminal duct lobular unit of the breast. IDC accounts for approximately 80% of cases and originates from the terminal ducts, whereas ILC (around 10%) arises from the mammary lobules. Clinically and pathologically, ILC is generally characterized by lower tumor grade, larger tumor size, less frequent lymph node metastasis, and a biomarker profile of ER+/PR+, HER2–, and low Ki- 67, which is associated with a more favorable prognosis compared to IDC. Therefore, analyzing the clinical and pathological differences between ILC and IDC is important to support more accurate prognostication and management.

Purpose: To analyze the differences in clinicopathological characteristics between ILC and IDC in breast cancer patients at RSUP Dr. Sardjito.

Method: This study is an analytical observational research with a cross-sectional design using medical record data of breast cancer patients diagnosed between 2021 and 2025 at RSUP Dr. Sardjito. The variables assessed included tumour size, lymph node status, lymphovascular invasion, tumor-infiltrating lymphocytes, tumor grade, and the expression of ER, PR, HER2, and Ki-67. Statistical analysis was performed using SPSS version 29.0.2.0.

Result: The frequency of ILC was 4.8%, while IDC accounted for 95.2%. Significant differences between the two subtypes were found in tumor grade (p < 0 xss=removed xss=removed xss=removed xss=removed xss=removed xss=removed xss=removed xss=removed>

Kata Kunci : Kanker payudara, Invasive Lobular Carcinoma (ILC), Invasive Ductal Carcinoma (IDC), Gambaran klinikopatologi, Prognosis