Sintesis Senyawa Alil Fenil Eter Epoksida serta Uji Aktivitasnya sebagai Antimalaria terhadap Plasmodium falciparum
Afra Calista Fatin Nugraha, Prof. Drs. Jumina, Ph.D.; Prof. Dra. Tutik Dwi Wahyuningsih, M.Si., Ph.D.
2026 | Skripsi | KIMIA
Sintesis senyawa alil fenil eter epoksida serta uji aktivitasnya terhadap Plasmodium falciparum telah dilakukan. Penelitian ini bertujuan untuk mensintesis senyawa epoksida berbasis fenol. Senyawa alil fenil eter disintesis melalui reaksi antara fenol dan alil bromida dalam pelarut DMF dan katalis K2CO3 dengan pengadukan selama 48 jam pada suhu ruang. Senyawa alil fenil eter epoksida disintesis melalui reaksi epoksidasi alkena antara alil fenil eter dengan m-CPBA dalam pelarut kloroform dengan metode refluks selama 6 jam pada suhu 50 °C dan dilanjutkan pengadukan selama 18 jam. Produk hasil sintesis dilakukan karakterisasi menggunakan instrumen GC-MS, FTIR, 1H-NMR, dan 13C-NMR. Uji aktivitas antimalaria senyawa alil fenil eter epoksida dilakukan secara in vitro terhadap Plasmodium falciparum strain FCR-3.
Sintesis alil fenil eter menghasilkan produk berwujud cairan kekuningan dengan persen hasil 92,5%. Sementara itu, sintesis alil fenil eter epoksida menghasilkan produk berwujud cairan coklat tua dengan persen hasil 77,3%. Uji aktivitas antimalaria senyawa alil fenil eter epoksida menunjukkan bahwa senyawa tersebut memiliki aktivitas penghambatan yang baik terhadap Plasmodium falciparum strain FCR-3 dengan nilai IC50 sebesar 7,499 ?g/mL.
Allyl phenyl ether epoxide was successfully synthesized and its activity was tested against Plasmodium falciparum. This study aims to synthesize phenol-based epoxide compounds. Allyl phenyl ether was synthesized by reacting phenol with allyl bromide in DMF using K2CO3 as a catalyst, followed by stirring for 48 hours at room temperature. Allyl phenyl ether epoxide was synthesized through the alkene epoxidation reaction between allyl phenyl ether and m-CPBA in chloroform using reflux method for 6 hours at 50 °C and stirring continuously for 18 hours. The synthesized products were characterized using GC-MS, FTIR, 1H-NMR, and 13C-NMR instruments. The antimalarial activity of allyl phenyl ether epoxide was tested in vitro against Plasmodium falciparum strain FCR-3.
The synthesis of allyl phenyl ether produced a yellowish liquid with a yield of 92.5%. Meanwhile, the synthesis of allyl phenyl ether epoxide produced a dark brown liquid with a yield of 77.3%. The antimalarial activity test of allyl phenyl ether epoxide showed good inhibitory activity against Plasmodium falciparum strain FCR-3 with an IC50 value of 7.499 ?g/mL.
Kata Kunci : alil fenil eter epoksida, antimalaria, epoksida, fenol, Plasmodium falciparum
