Background: Sepsis is a condition characterized by dysregulation of the immune response to infection, which can lead to organ dysfunction and death. Metabolic alterations in sepsis result in increased free fatty acids and triglyceride levels due to enhanced lipolysis in adipose tissue and decreased triglyceride clearance by hepatic lipoprotein lipase. Free fatty acids and triglycerides accumulate and exert toxic effects on mitochondria, triggering apoptosis and organ damage. Triglyceride levels are associated with the clinical course of sepsis and may influence sepsis severity; however, this relationship remains controversial.Objective: To evaluate the association between serum triglyceride levels and the severity of sepsis.Methods: This analytical observational study employed an unmatched case–control design involving patients with sepsis and septic shock admitted to the intensive care unit of Dr. Sardjito Hospital. Inclusion criteria included a SOFA score ?2, age ?18 years, and availability of serum triglyceride data during a single episode of sepsis hospitalization. Pregnant patients were excluded. Differences in categorical variables between the case group (septic shock) and control group (sepsis) were analyzed using the Chi-square test, while continuous variables were analyzed using the Mann–Whitney test with SPSS version 26.0. Triglyceride levels were presented as median and Q1–Q3. Multivariate analysis was performed using logistic regression. A p-value ?0.05 was considered statistically significant.Results: A total of 120 subjects were included, consisting of 89 cases (septic shock) and 31 controls (sepsis). Sepsis patients with triglyceride levels ?134 mg/dL had a 6.429-fold higher risk of developing septic shock compared to those with triglyceride levels Conclusion: Serum triglyceride levels ?134 mg/dL in patients with sepsis were found to be significantly associated with a 7.773-fold higher likelihood of septic shock compared with sepsis patients with triglyceride levels ">   Background: Sepsis is a condition characterized by dysregulation of the immune response to infection, which can lead to organ dysfunction and death. Metabolic alterations in sepsis result in increased free fatty acids and triglyceride levels due to enhanced lipolysis in adipose tissue and decreased triglyceride clearance by hepatic lipoprotein lipase. Free fatty acids and triglycerides accumulate and exert toxic effects on mitochondria, triggering apoptosis and organ damage. Triglyceride levels are associated with the clinical course of sepsis and may influence sepsis severity; however, this relationship remains controversial.Objective: To evaluate the association between serum triglyceride levels and the severity of sepsis.Methods: This analytical observational study employed an unmatched case–control design involving patients with sepsis and septic shock admitted to the intensive care unit of Dr. Sardjito Hospital. Inclusion criteria included a SOFA score ?2, age ?18 years, and availability of serum triglyceride data during a single episode of sepsis hospitalization. Pregnant patients were excluded. Differences in categorical variables between the case group (septic shock) and control group (sepsis) were analyzed using the Chi-square test, while continuous variables were analyzed using the Mann–Whitney test with SPSS version 26.0. Triglyceride levels were presented as median and Q1–Q3. Multivariate analysis was performed using logistic regression. A p-value ?0.05 was considered statistically significant.Results: A total of 120 subjects were included, consisting of 89 cases (septic shock) and 31 controls (sepsis). Sepsis patients with triglyceride levels ?134 mg/dL had a 6.429-fold higher risk of developing septic shock compared to those with triglyceride levels Conclusion: Serum triglyceride levels ?134 mg/dL in patients with sepsis were found to be significantly associated with a 7.773-fold higher likelihood of septic shock compared with sepsis patients with triglyceride levels ">
Laporkan Masalah

Hubungan Kadar Trigliserida Serum Dengan Derajat Keparahan Sepsis di Ruang Rawat Intensif RS Dr. Sardjito

Shinta Marito Br Hombing, Dr. dr. Umi S. Intansari, M.Kes., Sp.PK, Subsp. P.I.(K), Subsp. I.K.(K); Dr. dr. Andaru Dahesihdewi, M. Kes., Sp.PK, Subsp. P.I.(K), Subsp. Onk.K.(K)

2025 | Tesis | S2 Kedokteran Klinik

Latar belakang: Sepsis merupakan kondisi yang ditandai dengan disregulasi respon imun terhadap infeksi, yang dapat berujung pada disfungsi organ hingga kematian. Perubahan metabolik pada sepsis menyebabkan peningkatan asam lemak dan kadar trigliserida akibat adanya peningkatan lipolisis di jaringan adiposa dan penurunan pembersihan trigliserida oleh lipoprotein lipase di hati. Asam lemak bebas dan trigliserida menjadi terakumulasi dan bersifat toksik terhadap mitokondria, memicu apoptosis dan kerusakan organ. Kadar trigliserida berhubungan dengan perjalanan sepsis, mempengaruhi derajat keparahan sepsis, namun masih menjadi perdebatan. 

Tujuan: Mengevaluasi hubungan kadar trigliserida serum dengan derajat keparahan sepsis.

Metode: Penelitian observasional analitik dengan desain kasus kontrol tidak berpasangan melibatkan subjek pasien sepsis dan syok septik di ruang intensif RS Dr. Sardjito, yang memenuhi kriteria inklusi meliputi skor SOFA ? 2, usia ? 18 tahun, data trigliserida serum dalam satu episode rawat inap sepsis tersedia. Pasien hamil dieksklusi dari penelitian ini.  Uji beda variabel kategorik antara kelompok kasus (syok septik) dan kelompok kontrol (sepsis) menggunakan Chi-Square, sedangkan variabel kontinyu menggunakan  analisis uji Mann Whitney dari SPSS versi 26.0. Kadar  trigliserida dipresentasikan dalam median dan Q1; Q3. Analisis multivariat menggunakan regresi logistik. Nilai p ? 0,05 dianggap bermakna secara statistik.

Hasil: Penelitian ini melibatkan 120 subjek penelitian, yang terdiri dari 89 kelompok kasus (syok septik) dan 31 kelompok kontrol (sepsis). Kadar trigliserida ?134 mg/dL pada pasien sepsis ditemukan lebih tinggi  6,429 kali mendapatkan syok septik dibandingkan pasien sepsis dengan kadar trigliserida < 134 xss=removed>

Simpulan: Kadar trigliserida ?134 mg/dL pada pasien sepsis secara signifikan ditemukan lebih tinggi  7,773 kali pada kejadian syok septik dibandingkan pasien sepsis dengan kadar trigliserida < 134 class="Apple-converted-space"> 

Background: Sepsis is a condition characterized by dysregulation of the immune response to infection, which can lead to organ dysfunction and death. Metabolic alterations in sepsis result in increased free fatty acids and triglyceride levels due to enhanced lipolysis in adipose tissue and decreased triglyceride clearance by hepatic lipoprotein lipase. Free fatty acids and triglycerides accumulate and exert toxic effects on mitochondria, triggering apoptosis and organ damage. Triglyceride levels are associated with the clinical course of sepsis and may influence sepsis severity; however, this relationship remains controversial.

Objective: To evaluate the association between serum triglyceride levels and the severity of sepsis.

Methods: This analytical observational study employed an unmatched case–control design involving patients with sepsis and septic shock admitted to the intensive care unit of Dr. Sardjito Hospital. Inclusion criteria included a SOFA score ?2, age ?18 years, and availability of serum triglyceride data during a single episode of sepsis hospitalization. Pregnant patients were excluded. Differences in categorical variables between the case group (septic shock) and control group (sepsis) were analyzed using the Chi-square test, while continuous variables were analyzed using the Mann–Whitney test with SPSS version 26.0. Triglyceride levels were presented as median and Q1–Q3. Multivariate analysis was performed using logistic regression. A p-value ?0.05 was considered statistically significant.

Results: A total of 120 subjects were included, consisting of 89 cases (septic shock) and 31 controls (sepsis). Sepsis patients with triglyceride levels ?134 mg/dL had a 6.429-fold higher risk of developing septic shock compared to those with triglyceride levels <134 xss=removed>

Conclusion: Serum triglyceride levels ?134 mg/dL in patients with sepsis were found to be significantly associated with a 7.773-fold higher likelihood of septic shock compared with sepsis patients with triglyceride levels <134>

Kata Kunci : BUN, albumin, sepsis, kematian, BAR

  1. S2-2025-491983-abstract.pdf  
  2. S2-2025-491983-bibliography.pdf  
  3. S2-2025-491983-tableofcontent.pdf  
  4. S2-2025-491983-title.pdf