Pengaruh pemberian klonidin oral untuk mengurangi nyeri injeksi propofol

WIDHIARTAWAN, I Nyoman, Dr.Med.dr. Untung Widodo, SpAN.KIC

2004 | Tesis | PPDS I Anestesiologi dan Reanimasi

Tujuan : Mengetahui efek premedikasi klonidin 225 μg peroral untuk mengurangi nyeri akibat injeksi propofol. Desain : Randomized Controlled Trial dengan pembutaan ganda. Ruang lingkup : Pasien yang menjalani pembedahan terencana dengan anestesi umum di Gedung Bedah Sentral Terpadu (GBST) Rumah Sakit Dr. Sardjito Yogyakarta Subyek : Empat puluh pasien laki-laki atau perempuan, usia 18-60 tahun, berat badan 45-60 kg, Status fisik ASA I dan II. Intervensi : Subyek dibagi menjadi dua kelompok, masing-masing 20 pasien, kelompok perlakuan (klonidin 225 μg) dan kelompok kontrol (plasebo) diberikan 60 menit sebelum induksi propofol 2 mg/kgBB. Pengukuran utama : Nyeri akibat injeksi propofol dengan menggunakan Verbal Rating Scale, baik nyeri segera atau lambat dan ketika sadar dari anestesi umum. Hasil : Insiden dan derajat nyeri injeksi propofol lebih rendah pada kelompok klonidin dibanding kelompok plasebo (p<0,05). Kesimpulan : Premedikasi klonidin 225 μg peroral 60 menit sebelum induksi propofol mengurangi nyeri akibat injeksi propofol 2 mg/kgBB.

Objective : To know the premedication effect of clonidine 225 μg orally to reduce pain caused by propofol injection. Design : Double blind randomized controlled trial. Setting : Patients who underwent elective surgery using general anesthesia in central operating theatre Sardjito General Hospital Yogyakarta. Subject : Fourty patients, male or female age 18-60 years old, weight 45-60 kg, physical status ASA I-II. Intervention : Subjects were randomly divided into two groups, each group 20 patients. The treatment group received clonidine 225 μg p.o. and the control group received placebo about 60 minutes before the anesthetic induction with propofol 2 mg/kg body weight. Main measurement : Pain and the degree of pain at site of propofol injection were measured in all patients according to verbal rating scale, included immediately, delayed and emergence. Result : Incidence of pain due to propofol injection in clonidine lower than placebo group (p < 0.05). Conclusion : Oral premedication clonidine 225 μg 60 minutes before induction reduce pain caused by propofol injection.

Kata Kunci : Anestesi,Klonidin Oral,Nyeri Injeksi Propofol, Clonidine, pain due to propofol injection, propofol