Hubungan faktor prognosis konvensional dan faktor prognosis nonkonvensional karsinoma duktal infiltratif payudara

INDRAWATI, Prof.Dr.dr. Soeripto, SpPA

2004 | Tesis | PPDS I Patologi Anatomi

Latar Belakang. Kanker payudara merupakan tumor ganas yang memiliki perilaku heterogen. Faktor prognosis konvensional meliputi jumlah metastasis limfonodi aksila, derajat diferensiasi histologi dan besar tumor sangat penting untuk pengelolaan . Status faktor prognosis nonkonvensional meliputi indeks proliferasi MIB-1, ekspresi P53 dan ekspresi C-erbB2 juga mempunyai peranan . Tujuan. Mengetahui hubungan antara faktor prognosis konvensional meliputi jumlah metastasis limfonodi aksila, ukuran besarnya tumor dan derajat diferensiasi histologi dengan faktor prognosis nonkonvensional meliputi indeks proliferasi MIB-1, ekspresi P53 dan C-erb-B2 Cara penelitian. Penelitian observasional, potong lintang, menentukan hubungan antara jumlah metastasis limfonodi aksila, derajat diferensiasi histologi dan besar tumor dengan indeks proliferasi MIB-1, ekspresi P53 dan ekspresi CerbB2. Pemeriksaan indeks proliferasi MIB-1, ekspresi P53 dan C-erbB2 dilakukan dengan metoda imunohistokimia. Data dianalisis dengan korelasi Spearman Hasil dan kesimpulan. Jumlah metastasis limfonodi aksila menunjukkan hubungan bermakna dengan indeks proliferasi MIB-1 ( p < 0,01 ) dan ekspresi P53 ( p < 0,05 ) tetapi tidak menunjukkan hubungan bermakna dengan ekspresi C-erbB-2. Derajat diferensiasi histologi menunjukkan hubungan bermakna dengan indeks proliferasi MIB-1 ( p < 0,05 ) tetapi tidak menunjukkan hubungan bermakna dengan ekspresi P53 dan C-erbB-2. Besar tumor tidak menunjukkan hubungan bermakna baik dengan indeks proliferasi MIB-1, ekspresi P53 maupun C-erbB-2.

Background. Breast cancer has heterogenic biologic behaviour. Therefore, several prognostic parameters are important to determine adequate treatment. Conventional prognostic factors such as the number of axillary lymph node metastasis, histological grading and tumor size are important to determine adequate treatment . Nonconventional prognostic factors status are MIB-1 proliferation index, P53 and C-erbB-2 expression also have important role. Objective. To investigate correlation between conventional prognostic factors such as the number of axillary lymph node metastasis, histological grading and tumor size and nonconventional prognostic factors including MIB-1 proliferation index, P53 and C-erbB-2 expression . Methods. Cross sectional, observational study had been performed. Thirty cases of breast cancer tissues constituted the basis of the study. MIB-1 proliferation index, P53 and C-erbB-2 expressions were detected via immunohistochemical methods. Data were statistically analyzed with Spearman correlation. Results and Conclusion. There were significant correlation between the number of lymph node metastasis with MIB-1 proliferation index ( p < 0.01 ) and P53 expression ( p < 0,05 ) but there was no significant correlation between the number of lymph node metastasis with C-erbB-2 expression There was significant correlation between histological grading and MIB-1 proliferation index ( p < 0,05 ) but there were no significant correlation between histological grading with P53 and C-erbB-2 expression. There were neither significant correlation between tumor size with MIB-1 proliferation index nor P53 and CerbB- 2 expression

Kata Kunci : Kanker Payudara Prognosis Konvensional dan Nonkonvensional