Efektivitas Gatifloksasin 400 mg dosis tunggal dibandingkan Siprofloksasin 500 mg dosis tunggal pada pengobatan Uretritis Gonore tanpa komplikasi

WIDHYASTI, Ni Putu Ary, dr. Satiti Retno Pudjiati, SpKK

2004 | Tesis | S2 Ilmu Kedokteran Klinik

Uretritis gonore tanpa komplikasi (UG) merupakan penyakit menular seksual yang frekuensinya tertinggi di poliklinik kulit dan kelamin RS Dr. Sardjito Yogyakarta. Terapi lini pertama adalah siprofloksasin 500 mg dosis tunggal. Resistensi siprofloksasin untuk pengobatan UG semakin meningkat, sehingga diperlukan pengobatan UG yang lebih efektif. Gatifloksasin adalah golongan kuinolon generasi ketiga yang efektif terhadap Neisseria gonorrhoeae dengan berbagai keuntungan yang lebih dibandingkan siprofloksasin, serta belum dilaporkan terjadinya resistensi. Penelitian ini bertujuan untuk membandingkan hasil guna pengobatan UG antara kedua obat di atas. Luaran tambahan adalah data resistensi N.gonorrhoeae terhadap siprofloksasin dan gatifloksasin, serta cost effectiveness antara siprofloksasin dan gatifloksasin dalam pengobatan UG. Penelitian ini akan dilaksanakan di RS Dr Sardjito Yogyakarta dengan rancangan uji klinis acak buta ganda. Analisis statistik yang digunakan Chi square, Independent T test, dan Mantel Haenszel test.

The frequency of uncomplicated uretritis gonorrhea (UG) is still high among the sexually transmitted diseases in our clinics and ciprofloxacin is still being used as the first line treatment. After 10 years since ciprofloxacin widely used to treat UG, ciprofloksacin resistant has been reported from most of the countries, including Indonesia. Based on those reports it is urgently needed to reconsider a better treatment for UG. Gatifloxacin is a third quinolone generation that has several benefits, such as, 96 % oral bioavailability, not being influenced by food intake or milk, no interaction with cimetidine, warfarin, oxycodone, glibenclaminde, digoxine, theophyllin, enzym P450 and has not been reported of gonococcal resistant yet. The aim of this study is to compare between the effectiveness of gatifloxacin 400 mg single dose as the new treatment proposed and the use of ciprofloxacin 500 mg single dose for the treatment of UG. The other outcomes are ciprofloxacin and gatifloxacin resistant data, including the cost effectiveness of the two drugs. The paralleled double blind clinical trial will be conducted at Sardjito Hospital, Yogyakarta and statistically analized with Chi square, Independent T test, and Mantel Haenszel test .

Kata Kunci : Kulit dan Kelamin,Uretritis Gonore,Gatifloksasin,Siprofloksasin,uncomplicated urethritis gonorrhea, gatifloxacin, ciprofloxacin