The Relationship Between Severe COVID Prediction Estimate (SCOPE) Score and Disease Severity in Severe and Critical COVID-19 Patients

Kanza Rabani, dr. Heni Retno Wulan, M.Kes., Sp.PD-KP

2025 | Skripsi | PENDIDIKAN DOKTER

Latar Belakang: Severe COVID Prediction Estimate (SCOPE) score, yang dihitung dari D-dimer, C-reactive protein (CRP), ferritin, dan IL-6, digunakan untuk memprediksi derajat keparahan COVID-19. Semakin tinggi skor SCOPE, semakin besar risiko pasien mengalami kondisi kritis. Status COVID-19 kritis mengacu pada kondisi penyakit yang parah, di mana pasien membutuhkan dukungan ventilator mekanik atau obat vasopresor. Tujuan: Penelitian ini bertujuan untuk mengevaluasi hubungan antara Severe COVID Prediction Estimate (SCOPE) score dengan derajat keparahan penyakit pada pasien COVID-19 berat dan kritis. Metode: Penelitian ini merupakan studi retrospektif cross-sectional yang melibatkan populasi pasien COVID-19 berat dan kritis di RSUP dr. Sardjito pada tahun 2021. Data dianalisis berdasarkan SCOPE Score sebagai variabel independen dan derajat keparahan COVID-19 sebagai variabel dependen. Hasil: Penelitian ini menganalisis 274 rekam medis pasien COVID-19 berat dan kritis di RSUP dr. Sardjito. Hasil penelitian menunjukkan adanya hubungan signifikan antara SCOPE Score dan derajat keparahan penyakit. Pasien dengan SCOPE Score ?11 lebih sering diklasifikasikan sebagai kasus kritis (RR = 1.174, 95% CI: 1.049 – 1.314, p < 0 xss=removed xss=removed xss=removed>Kesimpulan: Penelitian ini mengonfirmasi adanya hubungan antara Severe COVID Prediction Estimate (SCOPE) Score dan derajat keparahan COVID-19 pada pasien COVID-19 berat dan kritis. SCOPE Score yang lebih tinggi (?11) berhubungan dengan peningkatan risiko penyakit kritis. Temuan ini menunjukkan bahwa SCOPE Score dapat digunakan sebagai alat untuk menilai risiko awal dan mendukung pengambilan keputusan klinis pada pasien COVID-19.

Background: The Severe COVID Prediction Estimate (SCOPE) score, derived from D-dimer, C-reactive protein (CRP), ferritin and IL-6, predicts the severity of COVID-19. A higher SCOPE score indicates an increased risk of critical disease. A critical COVID-19 status indicates a severe level of the COVID-19 disease where patients are in need of mechanical ventilator support or vasopressor drugs support. Objective: This study aims to evaluate the relationship between Severe COVID Prediction Estimate (SCOPE) score and disease severity in severe and critical COVID-19 patients. Method: A research population of severe and critical adult COVID-19 patients in RSUP dr. Sardjito in 2021 will be included in this retrospective cross-sectional study according to their SCOPE score and disease severity, with Severe COVID Prediction Estimate (SCOPE) score as the independent variable and COVID-19 disease severity as the dependent variable. Results: This study analyzed 274 medical records of severe and critical COVID-19 patients at RSUP dr. Sardjito. The findings showed a significant association between the Severe COVID Prediction Estimate (SCOPE) Score and disease severity. Patients with a SCOPE Score ?11 were more frequently classified as critical (RR = 1.174, 95% CI: 1.049 – 1.314, p < 0 xss=removed xss=removed xss=removed>Conclusion: This study confirms that there is a relationship between Severe COVID Prediction Estimate (SCOPE) Score and COVID-19 disease severity in severe and critical COVID-19 patients. A higher SCOPE Score (?11) is linked to an increased risk of critical disease severity. These findings suggest that the SCOPE Score may help in early risk assessment and clinical decision-making for COVID-19 patients

Kata Kunci : Severe COVID-19, Critical COVID-19, Disease severity, SCOPE score, Retrospective cross-sectional study