Akurasi Uji Lipoarabinomannan Assay Dibandingkan Kultur Mycobacterium Tuberculosis pada Pasien Tuberkulosis Pleura: Tinjauan Sistematis dan Meta-analisis
Rizqy Brillian Wahyudi, dr. Rizka Humardewayanti Asdie, Sp. PD-KPTI; dr. Heni Retnowulan, M. Kes., Sp. PD-KP
2025 | Skripsi | PENDIDIKAN DOKTER
Lipoarabinomannan (LAM) merupakan salah satu bagian
dari struktur Mycobacterium tuberculosis (MTB). MTB dapat bermanifestasi
di luar paru, salah satu bentuk terbanyaknya yaitu tuberkulosis pleura.
Penelitian ini menggunakan desain penitian tinjauan sistematis dan
meta-analisis untuk mengevaluasi akurasi uji diagnostik Lipoarabinomannan
Assay dibandingkan dengan uji baku emas.
Peneliti secara sistematis melakukan
pencarian literatur pada beberapa basis data yang mengandung kata kunci Population,
Intevention, Comparison, Outcome (PICO), kemudian
melakukan langkah-langkah penyaringan studi inklusi menggunakan protokol Preferred
Reporting Items for Systematic reviews and Meta-Analyses (PRISMA). Kualitas
studi inklusi dilakukan menggunakan Quality
Assessment of Diagnostic Accuracy Studies-2 (QUADAS-2). Data yang
telah diekstraksi dikumpulkan dengan model random effect dan kurva summary
receiver operating characteristic curves (SROC).
Dari enam
studi inklusi, dapat ditarik kesimpulan bahwa Lipoarabinomannan
Assay merupakan uji diagnostik yang memiliki spesifisitas tinggi sehingga LAM
Assay baik untuk modalitas diagnostik pasien TB pleura.
Lipoarabinomannan
(LAM) is part of the structure of Mycobacterium tuberculosis (MTB). MTB
can manifest outside the lungs, the most common form was pleural tuberculosis.
This study used a systematic review and meta-analysis design to evaluate the
accuracy of the Lipoarabinomannan Assay diagnostic test compared with the gold
standard test.
Researchers systematically conducted a literature search on several databases
containing the keywords Population, Intervention, Comparison, Outcome (PICO),
then carried out steps for inclusion study selection using the Preferred
Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) protocol. The
quality of included studies was assessed using the Quality Assessment of
Diagnostic Accuracy Studies-2 (QUADAS-2). The extracted data was collected
using random effect models and summary receiver operating characteristic curves
(SROC).
From the six
included studies, it can be concluded that the Lipoarabinomannan Assay is a
diagnostic test that has high specificity, so the LAM Assay is a good diagnostic modality for pleural TB patients.
Kata Kunci : akurasi, lipoarabinomannan, tuberkulosis, tuberkulosis pleura